Pediatric Clinical Pharmacology Training Bridgette L. Jones, MD MS Associate Professor Pediatrics, University of Missouri Kansas City American Academy of Pediatrics Chair, Committee on Drugs

No relevant conflicts of interest

NIH T32 Pediatric Clinical Pharmacology Fellowships Mandated through the BPCA 2007 legislation Provide training in pediatric clinical pharmacology Stimulate interdisciplinary collaboration among clinical, translational, and basic researchers in pediatric therapeutics research Enable the development of a pediatric pharmacology section within the adult clinical pharmacology department Purpose: help ensure that a diverse and highly trained workforce is available in an area that currently has a limited number of researchers. 

Children’s Mercy Pediatric Clinical Pharmacology Training Program Fully accredited by the American Board of Clinical Pharmacology (ABCP) Has formally trained 19 fellows since 1999 (pediatricians and clinical pharmacists, one pediatric nurse practitioner) Training model integrates pediatric clinical pharmacology with a primary pediatric subspecialty (e.g. Infectious Disease/Clinical Pharmacology, 4 year combined training)

Children’s Mercy Pediatric Clinical Pharmacology Training Program

Trainee 1 2 3 4 5** 6 7 8 9 10 12 13 Totals completed projects 15   15 # completed -basic # completed -clinical 11 # studies in progress 5 24 # basic studies in progress # clinical studies in progress 17 # publications 51 # original research publications 22 # scientific presentations 18 66 # peer-reviewed grants funded NIH-LRP yes no DNA K applied K awarded KL2 (CTSA) KL2 NASPGHAN * denotes program graduate ** denotes former ASCPT Presidential Trainee Award recipient DNA denotes "did not apply" N.B. Jean Dinh, PharmD, PhD entered program in July 2014 and to date, has no academic output while in the program updated July 2017

Former Trainees Jennifer Goldman MD MS, Infectious Disease KL2 R01 awarded 2018 Adverse Drugs Reactions, Bactrim Toxicity Jonathon Wagner DO, Cardiology Statin pharmacotherapeutics Valentina Shakhnovich, MD NASPHAGAN career development award Obesity in PPI pharmacology Ryan Funk PharmD PhD Biomarkers/pharmacology of disease modifying drugs in pediatric rheumatic disease

Trainings programs address a critical barrier in pediatric drug development Recognize gaps in knowledge and areas of need Tools and skillsets to address questions and alleviate barriers to pediatric drug development Conduct adequate/successful pediatric clinical trials

Susan Abdel-Rahman, Program Director Bridgette L. Jones, Associate Program Director bljones@cmh.edu https://www.childrensmercy.org/professional- education/fellowships/pediatric-clinical- pharmacology-fellowship/