Cardiovascular risk in normal weight, eumenorrheic, nonhirsute daughters of patients with polycystic ovary syndrome: a pilot study Cesare Battaglia,

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Presentation transcript:

Cardiovascular risk in normal weight, eumenorrheic, nonhirsute daughters of patients with polycystic ovary syndrome: a pilot study Cesare Battaglia, M.D., Ph.D., Fulvia Mancini, M.D., Arianna Cianciosi, M.D., Paolo Busacchi, M.D., Nicola Persico, M.D., Roberto Paradisi, M.D., Fabio Facchinetti, M.D., Domenico de Aloysio, M.D. Fertility and Sterility Volume 92, Issue 1, Pages 240-249 (July 2009) DOI: 10.1016/j.fertnstert.2008.05.018 Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Top left: Brachial artery diameter variations during reactive hyperemia. Bottom left: The percentage changes 15 minutes after the reactive hyperemia were not significantly different between patients with PCO and controls. At 120 minutes the reactive hyperemia was still present only in controls, being significantly greater than in patients with PCO (a = P=.0015). Top right: Brachial artery Doppler variations during reactive hyperemia. Bottom right: The percentage changes 15 minutes after the reactive hyperemia were not significantly different between patients with PCO and controls. At 120 minutes the reactive hyperemia was still present only in controls, being significantly greater than in patients with PCO (b = P<.001). Fertility and Sterility 2009 92, 240-249DOI: (10.1016/j.fertnstert.2008.05.018) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Top left: During OGTT, the basal circulating glucose levels were similar in patients with PCO and controls in all the women we observed. After oral glucose load, the glucose levels increased in the same way, in the two groups, up to 60 minutes. Afterward, it was possible to observe a rapid decline in controls. At 90 minutes, the glucose levels were significantly lower in eumenorrheic controls than in patients with PCO (a = P=.002). Similarly, after 120 minutes, the circulating glucose levels were lower in controls than in patients with PCO (b = P<.001). Top right: During OGTT, the basal insulin plasma levels were higher in women with PCO than in controls (c = P=.039). At 90 minutes (d = P=.048) and at 120 minutes (e = P=.01) the insulin circulating levels were higher in patients with PCO than in controls. Bottom: During OGTT, the C-peptide circulating levels, at 90 minutes from the oral glucose load, were higher (f = P=.038) in women with PCO than in other patients. After 120 minutes, the women affected by PCO showed higher C-peptide values than controls (g = P<.001). Fertility and Sterility 2009 92, 240-249DOI: (10.1016/j.fertnstert.2008.05.018) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions