Volume 147, Issue 6, Pages e21 (December 2014)

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Volume 147, Issue 6, Pages 1255-1266.e21 (December 2014) Development and Validation of a Symptom-Based Activity Index for Adults With Eosinophilic Esophagitis  Alain M. Schoepfer, Alex Straumann, Radoslaw Panczak, Michael Coslovsky, Claudia E. Kuehni, Elisabeth Maurer, Nadine A. Haas, Yvonne Romero, Ikuo Hirano, Jeffrey A. Alexander, Nirmala Gonsalves, Glenn T. Furuta, Evan S. Dellon, John Leung, Margaret H. Collins, Christian Bussmann, Peter Netzer, Sandeep K. Gupta, Seema S. Aceves, Mirna Chehade, Fouad J. Moawad, Felicity T. Enders, Kathleen J. Yost, Tiffany H. Taft, Emily Kern, Marcel Zwahlen, Ekaterina Safroneeva  Gastroenterology  Volume 147, Issue 6, Pages 1255-1266.e21 (December 2014) DOI: 10.1053/j.gastro.2014.08.028 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Conceptual framework for the development of EEsAI instruments. The EndoFlip or mucosal biomarkers, were not, as of yet, evaluated for the purposes of the EEsAI study. EndoFlip, Endolumenal Functional Lumen Imaging Probe. Gastroenterology 2014 147, 1255-1266.e21DOI: (10.1053/j.gastro.2014.08.028) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Box plots of patient-assessed EoE severity distribution by endoscopic/histologic activity. The box contains the 25th–75th percentiles of values, the horizontal line in the middle of the box represents the median. Eos, eosinophils. Gastroenterology 2014 147, 1255-1266.e21DOI: (10.1053/j.gastro.2014.08.028) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 (A) The correlation plot between the EEsAI PRO score and the PatGA in the validation group. (B) The Bland–Altman plot for the agreement between the EEsAI PRO score and the PatGA in the validation group. The grey box indicates the 95% limits of agreement. Gastroenterology 2014 147, 1255-1266.e21DOI: (10.1053/j.gastro.2014.08.028) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 1 Timetable for the adult EEsAI study. Gastroenterology 2014 147, 1255-1266.e21DOI: (10.1053/j.gastro.2014.08.028) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 2 Patient input. Gastroenterology 2014 147, 1255-1266.e21DOI: (10.1053/j.gastro.2014.08.028) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 3 Extract of the survey to gain patient input on EoE-related symptoms. Gastroenterology 2014 147, 1255-1266.e21DOI: (10.1053/j.gastro.2014.08.028) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 4 Conceptual model of the study. Gastroenterology 2014 147, 1255-1266.e21DOI: (10.1053/j.gastro.2014.08.028) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 5 Key domains of EoE-related symptoms. Gastroenterology 2014 147, 1255-1266.e21DOI: (10.1053/j.gastro.2014.08.028) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 6 The relationship between the PatGA of EoE severity and the PRO components that were chosen for the construction of the PRO score. The data for the 7-day recall period are shown. TS, trouble swallowing. Gastroenterology 2014 147, 1255-1266.e21DOI: (10.1053/j.gastro.2014.08.028) Copyright © 2014 AGA Institute Terms and Conditions

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