Nat. Rev. Cardiol. doi:10.1038/nrcardio.2016.203 Figure 4 Impaired mitochondrial energy production along the inner membrane Figure 4 | Impaired mitochondrial energy production along the inner membrane. Enzyme complexes responsible for energy production are packed into the mitochondrial inner membrane, often with the help of phospholipids such as cardiolipin. Failing mitochondria often display altered morphology, decreased ATP-generating capacity, heightened production of reactive oxygen species (ROS), abnormal cardiolipin levels, and impaired supercomplexes. Brown, D. A. et al. (2016) Mitochondrial function as a therapeutic target in heart failure Nat. Rev. Cardiol. doi:10.1038/nrcardio.2016.203