Two Families with Familial Amyotrophic Lateral Sclerosis Are Linked to a Novel Locus on Chromosome 16q Deborah M. Ruddy, Matthew J. Parton, Ammar Al-Chalabi,

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Two Families with Familial Amyotrophic Lateral Sclerosis Are Linked to a Novel Locus on Chromosome 16q Deborah M. Ruddy, Matthew J. Parton, Ammar Al-Chalabi, Cathryn M. Lewis, Caroline Vance, Bradley N. Smith, P. Nigel Leigh, John F. Powell, Teepu Siddique, Eelco Postumus Meyjes, Frank Baas, Vianney De Jong, Christopher E. Shaw The American Journal of Human Genetics Volume 73, Issue 2, Pages 390-396 (August 2003) DOI: 10.1086/377157 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 1 Pedigree drawing of families 1 and 2. Affected individuals are indicated by blackened diamonds. The informative marker alleles are shown. All inferred haplotypes reconstructed (in brackets) were done on the basis of minimal recombination. A hatched bar indicates the disease haplotype. Information is shown only for relevant individuals. The sex of all individuals has been disguised, and unaffected at-risk individuals have been omitted to preserve confidentiality. The American Journal of Human Genetics 2003 73, 390-396DOI: (10.1086/377157) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 1 Pedigree drawing of families 1 and 2. Affected individuals are indicated by blackened diamonds. The informative marker alleles are shown. All inferred haplotypes reconstructed (in brackets) were done on the basis of minimal recombination. A hatched bar indicates the disease haplotype. Information is shown only for relevant individuals. The sex of all individuals has been disguised, and unaffected at-risk individuals have been omitted to preserve confidentiality. The American Journal of Human Genetics 2003 73, 390-396DOI: (10.1086/377157) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 2 Graphical representation of the three-point LOD scores for F1 and F2 The American Journal of Human Genetics 2003 73, 390-396DOI: (10.1086/377157) Copyright © 2003 The American Society of Human Genetics Terms and Conditions