Covering the Cover Gastroenterology Anson W. Lowe, Richard H. Moseley  Gastroenterology  Volume 146, Issue 5, Pages 1139-1142 (May 2014) DOI: 10.1053/j.gastro.2014.03.030 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Percent of subjects who achieved the primary end point. ITT, intent-to-treat; PP, per protocol. Gastroenterology 2014 146, 1139-1142DOI: (10.1053/j.gastro.2014.03.030) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Post-transplantation patient survival of HPS transplant recipients based on room-air PaO2. Gastroenterology 2014 146, 1139-1142DOI: (10.1053/j.gastro.2014.03.030) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Clinical relevance of PTPN3 somatic mutations and protein expression in patients with ICC. (A) Kaplan–Meier curve shows that patients with ICC who had PTPN3 mutations had a significantly higher risk of recurrence than those with WT PTPN3 (log-rank test). (B) Kaplan–Meier curve showing TTR in patients with ICC with WT or mutant PTPN3 (log-rank test). (C) Quantitative reverse-transcription polymerase chain reaction shows no differences in PTPN3 mRNA expression between tumors with PTPN3 mutations (n = 42) or tumors with the L384H mutation (n = 16) and WT tumors (n = 29) (Mann–Whitney U test). (D) Representative immunohistochemical pictures showing PTPN3 protein expression in ICC tumors and normal intrahepatic bile duct. Scale bars = 100 μm. (E) Kaplan–Meier curve showing decreased TTR in patients with high PTPN3 expression vs low expression (log-rank test). Gastroenterology 2014 146, 1139-1142DOI: (10.1053/j.gastro.2014.03.030) Copyright © 2014 AGA Institute Terms and Conditions