Optimal timing for elective egg freezing Tolga B. Mesen, M.D., Jennifer E. Mersereau, M.D., M.S.C.I., Jennifer B. Kane, Ph.D., Anne Z. Steiner, M.D., M.P.H.  Fertility and Sterility  Volume 103, Issue 6, Pages 1551-1556.e4 (June 2015) DOI: 10.1016/j.fertnstert.2015.03.002 Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Simplified decision tree for model A. For a simplified representation of the decision tree, chance nodes for probability of second and third cycles from frozen oocytes, first and second (FET), and miscarriage are not shown. Analyses were repeated for decision ages from 25 to 40 years, assuming a 7-year time horizon before attempting pregnancy. In model A (requiring marriage to attempt conception), those who did not marry did not attempt pregnancy. In model B, all women attempt pregnancy, either with a partner or with donor sperm. Solid square denotes decision node; open circles denote chance nodes. Fertility and Sterility 2015 103, 1551-1556.e4DOI: (10.1016/j.fertnstert.2015.03.002) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 2 The y axis represents the probability of live birth at horizon age, which is 7 years after decision age. Decision age is presented on the x axis. Solid lines: oocyte cryopreservation (OC). Dashed lines: no action. Model A (red) represents women requiring marriage before attempting pregnancy. Model B (black) represents women who do not require marriage before attempting pregnancy (will attempt pregnancy with husband, donor sperm, or unmarried male partner). Fertility and Sterility 2015 103, 1551-1556.e4DOI: (10.1016/j.fertnstert.2015.03.002) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Cost per additional live birth at horizon age when electing to cryopreserve oocytes versus no action at decision age, which is presented on the x axis. Model A represents women requiring marriage before attempting pregnancy. Model B represents women who do not require marriage before attempting pregnancy (will attempt pregnancy with husband, donor sperm, or unmarried male partner). Fertility and Sterility 2015 103, 1551-1556.e4DOI: (10.1016/j.fertnstert.2015.03.002) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 The y axis represents the probability of occurrence at horizon age, which is 7 years after decision age. The x axis represents the decision age. Dashed lines in A–E represent error used in sensitivity analyses. Dotted portion of line in B represents projected data. For simplicity, variable errors are not graphed in F and G. Fertility and Sterility 2015 103, 1551-1556.e4DOI: (10.1016/j.fertnstert.2015.03.002) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 The y axis represent the probability of live birth at (A) 3- and (B) 5-year horizon age. Decision age is presented on the x axis. Solid lines: oocyte cryopreservation (OC). Dashed lines: no action. Model A represents women requiring marriage before attempting pregnancy. Model B represents women who do not require marriage before attempting pregnancy (will attempt pregnancy with husband, donor sperm, or unmarried male partner). Fertility and Sterility 2015 103, 1551-1556.e4DOI: (10.1016/j.fertnstert.2015.03.002) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions