Volume 156, Issue 1, Pages 254-272.e11 (January 2019) Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018  Anne F. Peery, Seth D. Crockett, Caitlin C. Murphy, Jennifer L. Lund, Evan S. Dellon, J. Lucas Williams, Elizabeth T. Jensen, Nicholas J. Shaheen, Alfred S. Barritt, Sarah R. Lieber, Bharati Kochar, Edward L. Barnes, Y. Claire Fan, Virginia Pate, Joseph Galanko, Todd H. Baron, Robert S. Sandler  Gastroenterology  Volume 156, Issue 1, Pages 254-272.e11 (January 2019) DOI: 10.1053/j.gastro.2018.08.063 Copyright © 2019 AGA Institute Terms and Conditions

Figure 1 (A) Temporal trend in hospitalizations with a principal diagnosis of chronic hepatitis C virus infection, NIS, 1993–2014. (B) Temporal trends in hospitalizations with any diagnosis or principal diagnosis of C difficile infection, NIS, 1993–2014. (C) Temporal trend in hospitalizations with principal diagnosis of intestinal obstruction, NIS, 1993–2014. Gastroenterology 2019 156, 254-272.e11DOI: (10.1053/j.gastro.2018.08.063) Copyright © 2019 AGA Institute Terms and Conditions

Figure 2 Temporal trends in ED visits, hospitalizations, and operations for appendicitis, NEDS and NIS 2006–2014. Gastroenterology 2019 156, 254-272.e11DOI: (10.1053/j.gastro.2018.08.063) Copyright © 2019 AGA Institute Terms and Conditions

Figure 3 (A) Age-adjusted incidence (2000 US standard population) of colorectal cancer by 10-year age group, US Cancer Statistics, 2000–2014. (B) Age-adjusted mortality (2000 US standard population) of colorectal cancer by 10-year age group, US Cancer Statistics, 2000–2014. Gastroenterology 2019 156, 254-272.e11DOI: (10.1053/j.gastro.2018.08.063) Copyright © 2019 AGA Institute Terms and Conditions

Figure 4 (A) Colonoscopies performed per 1000 enrollee-years, by age group, MarketScan Commercial Claims and Encounters and Medicare 2002–2013. (B) Upper endoscopies performed per 1000 enrollee-years, by age group, MarketScan Commercial Claims and Encounters and Medicare 2002–2013. (C) Flexible sigmoidoscopies performed per 1000 enrollee-years, by age group, MarketScan Commercial Claims and Encounters and Medicare 2002–2013. (D) ERCPs performed per 1000 enrollee-years, by age group, MarketScan Commercial Claims and Encounters and Medicare 2002–2013. (E) Upper endoscopic ultrasound performed per 1000 enrollee-years, by age group, MarketScan Commercial Claims and Encounters and Medicare 2002–2013. (F) Lower endoscopic ultrasound performed per 1000 enrollee-years, by age group, MarketScan Commercial Claims and Encounters and Medicare, 2002–2013. Gastroenterology 2019 156, 254-272.e11DOI: (10.1053/j.gastro.2018.08.063) Copyright © 2019 AGA Institute Terms and Conditions

Figure 5 (A) Adenomatous polyps on colonoscopy in screening only, ages 45–75 y, average-risk persons by age, sex, and race. (B) Advanced adenomatous polyps (≥10 mm, high-grade dysplasia, villous component) on colonoscopy in screening only, ages 45–75 y, average-risk persons by age, sex, and race. (C) Serrated polyps on colonoscopy in screening only, ages 45–75 y, average-risk persons by age, sex, and race. (D) Adenocarcinoma on colonoscopy in screening only, ages 50–75 y, average-risk persons by age, sex, and race. Gastroenterology 2019 156, 254-272.e11DOI: (10.1053/j.gastro.2018.08.063) Copyright © 2019 AGA Institute Terms and Conditions