Endothelial Cell Injury in Cardiovascular Surgery: The Systemic Inflammatory Response1 Edward M Boyle, MD, Timothy H Pohlman, MD, Marion C Johnson, MD,

Slides:

Advertisements

Similar presentations

Cytokine Responses to CPB Seoul National University Hospital Department of Thoracic & Cardiovascular Surgery.

Advertisements

Mechanism of Action of Colchicine in the Treatment of Gout

Pathogenesis, Diagnosis, and Treatment of Alcoholic Liver Disease

The STS National Database

Lucas R. Barbieri, MD, Domingos D. Lourenço-Filho, MD, PhD, Elaine R

Cytokine release and neutrophil activation are not prevented by heparin-coated circuits and aprotinin administration Jean-Olivier Defraigne, MD, PhD,

Adult Aortic Valve Interstitial Cells Have Greater Responses to Toll-Like Receptor 4 Stimulation Xin-Sheng Deng, MD, Xianzhong Meng, MD, PhD, QingChun.

Prevention of ischemia-reperfusion injury in cardiac surgery: Therapeutic strategies targeting signaling pathways Kay Maeda, MD, PhD, Marc Ruel, MD,

Primary Immunodeficiencies

Pretreatment with ω-3 fatty acid infusion to prevent leukocyte–endothelial injury responses seen in cardiac surgery Jonathan McGuinness, MD, PhD, John.

Association between n-3 polyunsaturated fatty acid content of red blood cells and inflammatory biomarkers in patients with peripheral artery disease

Association between n-3 polyunsaturated fatty acid content of red blood cells and inflammatory biomarkers in patients with peripheral artery disease

Aaron M. Abarbanell, MD, Arthur C. Coffey, MD, John W

Microvascular responses to sepsis: clinical significance

Tumor necrosis factor: Biology and therapeutic inhibitors

Functional Roles of Tumor Necrosis Factor-Alpha and Interleukin 1-Beta in Hypoxia and Reoxygenation Heather E. Merry, MD, Patrick Phelan, MD, Matthew.

Georges Makhoul, MD, MS, Ray C.J. Chiu, MD, PhD, Renzo Cecere, MD, MS

Mechanisms of myocardial reperfusion injury

P38 Mitogen Activated Protein Kinase Mediates Both Death Signaling and Functional Depression in the Heart Meijing Wang, MD, Ben M. Tsai, MD, Mark W.

Xenobiotic receptor meets NF-κB, a collision in the small bowel

Craig H Selzman, MD, Stephanie A Miller, MD, Alden H Harken, MD

Time-dependent cellular population of textured-surface left ventricular assist devices contributes to the development of a biphasic systemic procoagulant.

Regarding “Prospective evaluation of postimplantation syndrome evolution on patient outcomes after endovascular aneurysm repair for abdominal aortic aneurysm”

Andrew D. Shaw, MB, Ara A. Vaporciyan, MD, Xifeng Wu, MD, Terri M

CTSNet: a unique educational vehicle

Gene expression of inflammatory mediators in different chambers of the human heart Guro Valen, MD, PhD, Gabrielle Paulsson, PhD, Anna M Bennet, Göran.

Heterotopic pancreas of the esophagus masquerading as Boerhaave’s syndrome R.Thomas Temes, MD, Michael J Menen, MD, Michael S Davis, MD, Stuart B Pett,

Robert J Korst, MD, Ronald G Crystal, MD

Toll-Like Receptor 4 Mediates Lung Ischemia-Reperfusion Injury

Daniel R. Meldrum, MD, Brian D

Jo-Ellen Murphy, Caroline Robert, Thomas S. Kupper

William T. Mahle, MD, Emilia Matthews, MS, Kirk R. Kanter, MD, Brian E

Human cytokine responses to coronary artery bypass grafting with and without cardiopulmonary bypass Martin Strüber, MD, Jochen T Cremer, MD, Bernhard.

Activation of Endothelial and Coagulation Systems in Left Ventricular Assist Device Recipients Ranjit John, MD, Sandhya Panch, MBBS, Jennifer Hrabe,

The inflammatory response.

Anaphylactoid reactions to protamine: An often lethal complication in insulin-dependent diabetic patients undergoing vascular surgery Sushil K. Gupta,

Endothelial expression of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 is suppressed by postbypass plasma containing increased.

Thrombosis and Inflammatory Bowel Disease

Jeffrey M. Rhodes, MD, Anna F. Tilberg, MS, Robert R.M. Gifford, MD

Reducing lipids for CV protection in CKD patients—current evidence

Secretory Phospholipase A2 Inhibition Attenuates Intercellular Adhesion Molecule-1 Expression in Human Esophageal Adenocarcinoma Cells Miral R. Sadaria,

Support Your Specialty

Correction Journal of Vascular Surgery

Sustained release of milrinone delivered via microparticles in a rodent model of myocardial infarction Hamood Al Kindi, MD, Arghya Paul, PhD, Zhipeng.

Pathogenesis, Diagnosis, and Treatment of Alcoholic Liver Disease

Editorial Board, January 2010

Stroke induces inflammatory activation of the aortic endothelium

Interleukin-6 and “complex” cardiac myxoma

Transfusion-Related Acute Lung Injury

Myocardial Revascularization by Left Ventricular Assisted Beating Heart Is Associated With Reduced Systemic Inflammatory Response Paolo Stassano, MD,

No benefit of reduced heparinization in thoracic aortic operation with heparin-coated bypass circuits Christian Olsson, MD, Agneta Siegbahn, MD, PhD,

Pressure distension stimulates the expression of endothelial adhesion molecules in the human saphenous vein graft Massimo Chello, MD, Pasquale Mastroroberto,

Ronald A. Bronicki, MD, Carl L. Backer, MD, Harris P

Treating myocardial ischemia-reperfusion injury by targeting endothelial cell transcription Edward M Boyle, MD, Timothy G Canty, MD, Elizabeth N Morgan,

Aprotinin Enhances the Endogenous Release of Interleukin-10 After Cardiac Operations Gary E Hill, Robert P Diego, Alfred H Stammers, Suzanne M Huffman,

Tai Ji: The law of inflammatory response

Apparently, size matters…in congenital heart disease and brain injury

William H. Pearce, MD, Iliana Sweis, MD, James S. T. Yao, MD, Walter J

Neal S Goldstein, MD The Annals of Thoracic Surgery

Novel aspects of complement in kidney injury

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

Endothelial Cell Injury in Cardiovascular Surgery

Tumor necrosis factor: Biology and therapeutic inhibitors

Endogenous interleukin-4 and interleukin-10 regulate experimental lung ischemia reperfusion injury Alexander S Farivar, MD, Baiya Krishnadasan, MD, Babu.

Joachim Boldt, Bernd Kumle, Michael Papsdorf, Gunter Hempelmann

Deborah J. Kozik, DO, James S. Tweddell, MD

Edward M. Boyle, Timothy H. Pohlman, Carol J. Cornejo, Edward D

Removal of an intrathoracic migrated fixation pin by thoracoscopy

The Impact of New Technology on Cardiothoracic Surgical Practice

Balance of proinflammatory and antiinflammatory cytokines at thoracic cancer operation Darryl M Atwell, MD, Katherine P Grichnik, MD, Mark F Newman, MD,

Presentation transcript:

Endothelial Cell Injury in Cardiovascular Surgery: The Systemic Inflammatory Response1 Edward M Boyle, MD, Timothy H Pohlman, MD, Marion C Johnson, MD, Edward D Verrier, MD The Annals of Thoracic Surgery Volume 63, Issue 1, Pages 277-284 (January 1997) DOI: 10.1016/S0003-4975(96)01061-2

Fig. 1 The disseminated intravascular postpump syndrome. (ICAM = intracellular adhesion molecule; IL = interleukin; TNF = tumor necrosis factor; VCAM = vascular cell adhesion molecule.) The Annals of Thoracic Surgery 1997 63, 277-284DOI: (10.1016/S0003-4975(96)01061-2)

Fig. 2 The classic and alternative pathways of complement activation. The classic pathway requires an antigen-antibody complex to be formed. This occasionally happens when protamine is given to reverse heparin. The alternative pathway is nonspecific, and can be activated by foreign surfaces and the surface of endotoxin. When complement is activated, soluble factors, such as C5a and C3a, are released into the circulation. The Annals of Thoracic Surgery 1997 63, 277-284DOI: (10.1016/S0003-4975(96)01061-2)

Fig. 3 Signal transduction through NF-kB. (ICAM = intracellular adhesion molecule; IL-1 = interleukin-1; LPS = lipopolysaccharide; TNF = tumor necrosis factor.) The Annals of Thoracic Surgery 1997 63, 277-284DOI: (10.1016/S0003-4975(96)01061-2)