Confocal fluorescence microscopical images of 3-nitrotyrosine-positive blood vessels from a patient with mitochondrial disease. Confocal fluorescence microscopical.

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Confocal fluorescence microscopical images of 3-nitrotyrosine-positive blood vessels from a patient with mitochondrial disease. Confocal fluorescence microscopical images of 3-nitrotyrosine-positive blood vessels from a patient with mitochondrial disease.A, Shows the localization of 3-nitrotyrosine (green) to endothelial cells, labeled with UEA-I (red). Capillaries do not stain with 3-nitrotyrosine. B, shows a partial colocalization of 3-nitrotyrosine (green) to smooth muscle cells, labeled with actin (red) whereas in panel C 3-nitrotyrosine is localized to almost all the smooth muscle cells of the vessel wall. Gaetano Vattemi et al. Mol Cell Proteomics 2011;10:M110.002964 © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.