Level of Asthma Controller Therapy Before Admission to the Hospital

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Level of Asthma Controller Therapy Before Admission to the Hospital Manon Belhassen, MSc, Carole Langlois, MSc, Laurent Laforest, MD, PhD, Alexandra Lelia Dima, PhD, Marine Ginoux, MSc, Mohsen Sadatsafavi, MD, PhD, Eric Van Ganse, MD, PhD The Journal of Allergy and Clinical Immunology: In Practice Volume 4, Issue 5, Pages 877-883 (September 2016) DOI: 10.1016/j.jaip.2016.06.012 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Flow chart. Between 2006 and 2014, we identified 73,692 patients with 3 or more dispensations for asthma-related medications during any 12-month period. Among selected patients, 30.6% were aged 6 to 40 years at the third dispensation. We excluded 259 patients with COPD, 27 patients with CF, and 5 patients taking omalizumab. We finally selected 275 patients (1.5%) with asthma-related hospitalization of 12 months or more after the entry date. CF, Cystic fibrosis; COPD, chronic obstructive pulmonary disease. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, 877-883DOI: (10.1016/j.jaip.2016.06.012) Copyright © 2016 The Authors Terms and Conditions

Figure 2 Clusters of patients before asthma-related hospitalization (n = 275). A, Dendrogram: The vertical axis represents the distance or dissimilarity between clusters. The horizontal axis represents the patients. Each joining (fusion) of 2 clusters is represented on the graph by the splitting of a vertical line into 2 vertical lines. The vertical position of the split, shown by the short horizontal bar, gives the distance (dissimilarity) between the 2 clusters. B, Cluster plot: The vertical axis and the horizontal axis represent the canonical variables 1 and 2. Hierarchical clustering is based on the core idea of objects being more related to nearby objects than to objects farther away. These algorithms connect “objects” to form “clusters” on the basis of their distance. A cluster can be described largely by the maximum distance needed to connect parts of the cluster. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, 877-883DOI: (10.1016/j.jaip.2016.06.012) Copyright © 2016 The Authors Terms and Conditions