Effects of Blood Transfusion on Cause-Specific Late Mortality After Coronary Artery Bypass Grafting—Less Is More Thomas A. Schwann, MD, Joseph R. Habib,

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Effects of Blood Transfusion on Cause-Specific Late Mortality After Coronary Artery Bypass Grafting—Less Is More Thomas A. Schwann, MD, Joseph R. Habib, BS, Jawad M. Khalifeh, BS, Victor Nauffal, MD, Mark Bonnell, MD, Christopher Clancy, MD, Milo C. Engoren, MD, Robert H. Habib, PhD The Annals of Thoracic Surgery Volume 102, Issue 2, Pages 465-473 (August 2016) DOI: 10.1016/j.athoracsur.2016.05.023 Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Fifteen-year cumulative (cum.) incidence functions in coronary artery bypass graft surgery (CABG) patients compared for transfusion (Txn [red lines]) versus no-transfusion (NoTxn [black lines]) for (A) all-cause deaths, (B) cardiac mortality, and (C) noncardiac mortality. Analyses were done based on all patients (top panels) and repeated for patients having complications (middle panels) versus patients not having complications (bottom panels). All-cause death was cardiac plus noncardiac plus unknown-cause deaths; all pairwise comparisons were done by competing risks regression analysis. (HR = hazard ratio.) The Annals of Thoracic Surgery 2016 102, 465-473DOI: (10.1016/j.athoracsur.2016.05.023) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Forest plots showing transfusion (Txn) versus no-transfusion (NoTxn) 15-year mortality hazard ratio (HR) with 95% confidence interval (C.I.) for complicated (Compl [blue]), not complicated (No Compl [black]), and overall patient population (All PTS [gray]). (Left) Unadjusted HR (open symbols) and covariate-adjusted hazard ratio (AHR [closed symbols]) based on overall study cohort; (right) match-adjusted HR based on propensity matched patients only (HR <1 favors transfusion; HR >1 favors no transfusion). The Annals of Thoracic Surgery 2016 102, 465-473DOI: (10.1016/j.athoracsur.2016.05.023) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions