Body mass index, weight gain, and other determinants of lung function decline in adult asthma Alessandro Marcon, MSc, Angelo Corsico, MD, PhD, Lucia.

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Presentation transcript:

Body mass index, weight gain, and other determinants of lung function decline in adult asthma Alessandro Marcon, MSc, Angelo Corsico, MD, PhD, Lucia Cazzoletti, MSc, Massimiliano Bugiani, MD, Simone Accordini, MSc, Enrique Almar, MD, Isa Cerveri, MD, David Gislason, MD, Amund Gulsvik, MD, PhD, Christer Janson, MD, Deborah Jarvis, MD, Jesús Martínez- Moratalla, MD, Isabelle Pin, MD, Roberto de Marco, PhD Journal of Allergy and Clinical Immunology Volume 123, Issue 5, Pages 1069-1074.e4 (May 2009) DOI: 10.1016/j.jaci.2009.01.040 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Baseline FEV1 by categories of baseline BMI for men and women without airflow obstruction at baseline. Medians with Q1-Q3 are reported. The number of subjects in the BMI categories <20, 20-24.9, 25-30, and >30 kg/m2 are 12, 134, 71, and 7 (men) and 51, 182, 52, and 35 (women), respectively. Journal of Allergy and Clinical Immunology 2009 123, 1069-1074.e4DOI: (10.1016/j.jaci.2009.01.040) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Plot of FEV1 decline vs baseline BMI, and of the curve representing the FEV1 decline predicted on the basis of a linear regression on BMI and BMI squared, in men and women without airflow obstruction at baseline. Journal of Allergy and Clinical Immunology 2009 123, 1069-1074.e4DOI: (10.1016/j.jaci.2009.01.040) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Mean FEV1 decline (adjusted for all the covariates considered in the multivariate analysis) by categories of BMI gain (according to tertiles) for men and women without airflow obstruction at baseline. P value for trend: P < .001 (men) and P =.001 (women). Journal of Allergy and Clinical Immunology 2009 123, 1069-1074.e4DOI: (10.1016/j.jaci.2009.01.040) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions