Small macrophages are present in early childhood respiratory disease

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Presentation transcript:

Small macrophages are present in early childhood respiratory disease Luke W. Garratt, Adam K.A. Wright, Sarath C. Ranganathan, Jonathan Grigg, Peter D. Sly Journal of Cystic Fibrosis Volume 11, Issue 3, Pages 201-208 (May 2012) DOI: 10.1016/j.jcf.2011.11.008 Copyright © 2011 European Cystic Fibrosis Society Terms and Conditions

Fig. 1 Flow chart of identifying macrophage population for assessing size distribution. Sputum or BAL cells were stained with anti-CD14-APC, anti-HLA-DR-PerCP, anti-CD66b-FITC, anti-CD68-PE and anti-CD45-APC-Cy7 and data acquired by flow cytometry. The flow chart depicts the process of selecting the lung macrophage population of interest following acquisition. Journal of Cystic Fibrosis 2012 11, 201-208DOI: (10.1016/j.jcf.2011.11.008) Copyright © 2011 European Cystic Fibrosis Society Terms and Conditions

Fig. 2 Small macrophages in adult sputa. This figure provides a comparison between adult CF sputum with predominantly small macrophage (a) and adult CF sputum with predominantly large AMΦ (b). Journal of Cystic Fibrosis 2012 11, 201-208DOI: (10.1016/j.jcf.2011.11.008) Copyright © 2011 European Cystic Fibrosis Society Terms and Conditions

Fig. 3 Small macrophages in paediatric BAL. This figure provides a comparison between representative samples of BAL from a child with cystic fibrosis (a) and a disease control (b). Journal of Cystic Fibrosis 2012 11, 201-208DOI: (10.1016/j.jcf.2011.11.008) Copyright © 2011 European Cystic Fibrosis Society Terms and Conditions

Fig. 4 Relationship between number of small macrophages and number of neutrophils. Absolute number of small macrophages for each sample (y-axis), calculated for each sample by multiplying the fraction of small macrophages by the number of macrophages measured in BAL, plotted against the absolute number of neutrophils measured in BAL (x-axis). The rs value represents the Spearman correlation. Journal of Cystic Fibrosis 2012 11, 201-208DOI: (10.1016/j.jcf.2011.11.008) Copyright © 2011 European Cystic Fibrosis Society Terms and Conditions

Fig. 5 Relationship between proportion of small macrophages and proportion of blood monocytes. Data are reported as percentage of small macrophages for each sample (y-axis) as described above and plotted against the percentage of monocytes, calculated by monocyte count/mL of the total white cell count/mL (x-axis). The rp value represents the Pearson correlation. Journal of Cystic Fibrosis 2012 11, 201-208DOI: (10.1016/j.jcf.2011.11.008) Copyright © 2011 European Cystic Fibrosis Society Terms and Conditions