Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation Jacques Donnez,

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Presentation transcript:

Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation Jacques Donnez, M.D., Ph.D., Marie-Madeleine Dolmans, M.D., Ph.D., Antonio Pellicer, M.D., Ph.D., Cesar Diaz-Garcia, M.D., Maria Sanchez Serrano, M.D., Kristen Tryde Schmidt, M.D., Ph.D., Erik Ernst, M.D., Ph.D., Valérie Luyckx, M.D., Claus Yding Andersen, M.Sc., D.M.Sc. Fertility and Sterility Volume 99, Issue 6, Pages 1503-1513 (May 2013) DOI: 10.1016/j.fertnstert.2013.03.030 Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Ovarian cortex reimplantation on the ovarian medulla. Large pieces of thawed ovarian cortex are sutured to the medulla. From Donnez et al., 2006 (1). Fertility and Sterility 2013 99, 1503-1513DOI: (10.1016/j.fertnstert.2013.03.030) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Ovarian cortex reimplantation in a peritoneal pocket. Large pieces of ovarian cortex are placed in a peritoneal pocket. From Donnez et al., 2012 (31). Fertility and Sterility 2013 99, 1503-1513DOI: (10.1016/j.fertnstert.2013.03.030) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Ovarian cortical biopsy demonstrating the distance between the mesothelium and primordial follicles, ranging from 414 μm to 617 μm. Fertility and Sterility 2013 99, 1503-1513DOI: (10.1016/j.fertnstert.2013.03.030) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Impact of grafting on the resting follicle pool: potential influence of c-Kit/Kit ligand (KL), hypoxia, and antimüllerian hormone (AMH). From David et al. (65). Fertility and Sterility 2013 99, 1503-1513DOI: (10.1016/j.fertnstert.2013.03.030) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 5 Fertility preservation methods in women at risk of POF depending on patient age and possible delay before starting chemotherapy. Fertility and Sterility 2013 99, 1503-1513DOI: (10.1016/j.fertnstert.2013.03.030) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions