Endothelial Injury, Neutrophil Extracellular Traps, and Complement Activation in Thrombotic Microangiopathy and GVHD Nicholas J. Gloude, Sonata Jodele,

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Presentation transcript:

Endothelial Injury, Neutrophil Extracellular Traps, and Complement Activation in Thrombotic Microangiopathy and GVHD Nicholas J. Gloude, Sonata Jodele, Nathan Luebbering, Kelly E. Lake, Adam Lane, Stella M. Davies Biology of Blood and Marrow Transplantation Volume 23, Issue 3, Pages S232-S233 (March 2017) DOI: 10.1016/j.bbmt.2016.12.458 Copyright © 2016 Terms and Conditions

Figure 1 NETs rise during treatment and fall with resolution of TA-TMA. Biology of Blood and Marrow Transplantation 2017 23, S232-S233DOI: (10.1016/j.bbmt.2016.12.458) Copyright © 2016 Terms and Conditions

Figure 2 (A) NETS elevated in children with GVHD prior to TA-TMA therapy. (B) NETs persistently elevated in children with GVHD following resolution of TA-TMA. Biology of Blood and Marrow Transplantation 2017 23, S232-S233DOI: (10.1016/j.bbmt.2016.12.458) Copyright © 2016 Terms and Conditions

Figure 3 1. Chemotherapy, radiation, & infection; 2. Neutrophil activation; 3. NET formation and complement activation; 4. (A) TMA and (B) TMA + GVHD; 5. Resolution of TMA. Biology of Blood and Marrow Transplantation 2017 23, S232-S233DOI: (10.1016/j.bbmt.2016.12.458) Copyright © 2016 Terms and Conditions