EASL Clinical Practice Guidelines on hepatitis E virus infection Harry R. Dalton, Nassim Kamar, Sally A. Baylis, Darius Moradpour, Heiner Wedemeyer, Francesco Negro Harry R. Dalton, Nassim Kamar, Sally A. Baylis, Darius Moradpour, Heiner Wedemeyer, Francesco Negro  Journal of Hepatology  Volume 68, Issue 6, Pages 1256-1271 (June 2018) DOI: 10.1016/j.jhep.2018.03.005 Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Diagnostic algorithm for HEV infection. Serology and NAT testing are best used in combination, as a negative PCR does not exclude acute infection; serology is sometimes negative in the immunosuppressed patients with chronic infection. HEV, hepatitis E virus; NAT, nucleic acid amplification techniques. Journal of Hepatology 2018 68, 1256-1271DOI: (10.1016/j.jhep.2018.03.005) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Treatment algorithm for chronic HEV infection. The first therapeutic manoeuvre in transplant recipients is to reduce the dose of immunosuppression if possible. This will allow HEV to be cleared in about 30% of patients. If this is not possible, or unsuccessful, clinicians should follow the illustrated treatment algorithm. The role of other therapies such as sofosbuvir and immunoglobulins remains to be determined. HEV, hepatitis E virus. Journal of Hepatology 2018 68, 1256-1271DOI: (10.1016/j.jhep.2018.03.005) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Journal of Hepatology 2018 68, 1256-1271DOI: (10. 1016/j. jhep. 2018 Copyright © 2018 European Association for the Study of the Liver Terms and Conditions