Takashi Ehara, Hidekazu Shigematsu Kidney International

Slides:

Advertisements

Similar presentations

Volume 62, Issue 6, Pages (December 2002)

Advertisements

Volume 62, Issue 1, Pages (July 2002)

Tiffany Shao, Jordan Weinstein, Serge Jothy, Marc Goldstein

Volume 64, Issue 6, Pages (December 2003)

Acute kidney injury following proton pump inhibitor therapy

Volume 68, Issue 6, Pages (December 2005)

Volume 63, Issue 4, Pages (April 2003)

Volume 54, Issue 1, Pages (July 1998)

Organogenesis of the endocrine pancreas

Tadpole cells in an unstained urine sediment

The Case ∣ Acute renal failure and anemia

Volume 62, Issue 1, Pages (July 2002)

Volume 56, Issue 5, Pages (November 1999)

Volume 66, Issue 1, Pages (July 2004)

Volume 61, Issue 2, (February 2002)

Volume 85, Issue 2, Pages (January 2014)

Volume 56, Issue 3, Pages (September 1999)

Volume 73, Issue 12, Pages (June 2008)

Yang Wang, Yi Ping Wang, Yuet-Ching Tay, David C.H. Harris

Volume 77, Issue 9, Pages (May 2010)

Volume 58, Issue 1, Pages (July 2000)

The clinical spectrum of tubulointerstitial nephritis

Nrf2-deficient female mice develop lupus-like autoimmune nephritis1

Volume 57, Issue 2, Pages (October 2000)

How to interpret the eGFR in patients with small body surface area

Volume 68, Issue 6, Pages (December 2005)

Mohammed S. Razzaque, Ph.D., Takashi Taguchi Kidney International

Volume 62, Issue 4, Pages (October 2002)

Histochemical and Immunohistochemical Markers for Human Eccrine and Apocrine Sweat Glands: An Aid for Histopathologic Differentiation of Sweat Gland Tumors

Leah A. Haseley, Christian Hugo, Michael A. Reidy, Richard J. Johnson

Volume 59, Issue 4, Pages (April 2001)

Volume 54, Issue 2, Pages (August 1998)

Volume 60, Issue 1, Pages (July 2001)

Chun Shia Chang, R. Gary Kirk, Ping Lee Kidney International

Volume 67, Issue 1, Pages (January 2005)

Uromodulin storage disease

Myeloma cast nephropathy, direct renal infiltration by myeloma, and renal extramedullary hematopoiesis S.H. Nasr, B.B. Alobeid, J.A. Otrakji, G.S. Markowitz

Volume 70, Issue 11, Pages (December 2006)

Volume 62, Issue 5, Pages (November 2002)

Volume 63, Issue 4, Pages (April 2003)

Local macrophage proliferation in human glomerulonephritis

Volume 64, Issue 3, Pages (September 2003)

Volume 61, Issue 6, Pages (June 2002)

Volume 76, Issue 5, Pages (September 2009)

The Case | Idiopathic hypocomplementemic interstitial nephritis

Only anti-CD133 antibodies recognizing the CD133/1 or the CD133/2 epitopes can identify human renal progenitors Maria L. Angelotti, Elena Lazzeri, Laura.

Volume 74, Issue 6, Pages (September 2008)

Volume 62, Issue 2, Pages (August 2002)

A Pathogenic Role for IgE in Autoimmunity: Bullous Pemphigoid IgE Reproduces the Early Phase of Lesion Development in Human Skin Grafted to nu/nu Mice

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Distribution of postsynaptic density proteins in rat kidney: Relationship to neuronal nitric oxide synthase Akihiro Tojo, David S. Bredt, Christopher.

Volume 87, Issue 3, Pages (March 2015)

Volume 53, Issue 4, Pages (April 1998)

Immigrating progenitor cells contribute to human podocyte turnover

Fabry disease: An underrecognized cause of proteinuria

Lipid-binding proteins in rat and human kidney

Contribution of tubular injury to loss of remnant kidney function

Volume 60, Issue 5, Pages (November 2001)

The treatment of acute interstitial nephritis: More data at last

Organ transplantation goes to the movies

Accelerated expression of senescence associated cell cycle inhibitor p16INK4A in kidneys with glomerular disease B. Sis, A. Tasanarong, F. Khoshjou,

Volume 80, Issue 10, Pages (November 2011)

Class IV-S versus class IV-G lupus nephritis: Clinical and morphologic differences suggesting different pathogenesis Gary S. Hill, Michel Delahousse,

The more or less ‘pristine’ renal allograft biopsy

Lack of Membrane Expression of Interleukin-2 Receptor α Chain (CD25) in Mycosis Fungoides: Application of Laser Scanning Cytometry for Phenotyping of.

J.S. Schlondorff, G.P. Mendez, H.G. Rennke, C.C. Magee

The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury? Richard E. Gilbert, Mark E. Cooper Kidney.

Volume 70, Issue 9, Pages (November 2006)

Volume 65, Issue 1, Pages (January 2004)

Presentation transcript:

Contribution of mast cells to the tubulointerstitial lesions in IgA nephritis Takashi Ehara, Hidekazu Shigematsu Kidney International Volume 54, Issue 5, Pages 1675-1683 (November 1998) DOI: 10.1046/j.1523-1755.1998.00159.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Toluidine blue pH 5.0 (a) and pH 0.5 (b) staining of a control case. A mast cell with round nuclei and metachromatically (a) or orthochromatically (b) stained granules is found in the interstitium between tubules. Toluidine blue pH 0.5 was counterstained with nuclear fast red (×900). Kidney International 1998 54, 1675-1683DOI: (10.1046/j.1523-1755.1998.00159.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Immunostaining with anti-tryptase monoclonal antibody of a 25-year-old female with IgA nephritis. A mast cell that is polygonal in shape with cytoplasmic processes can be seen (counterstained with methylgreen; ×900). Kidney International 1998 54, 1675-1683DOI: (10.1046/j.1523-1755.1998.00159.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Anti-tryptase monoclonal staining of a 23-year-old female with IgA nephritis. Mast cells (arrows) have infiltrated the tubules (×350). Kidney International 1998 54, 1675-1683DOI: (10.1046/j.1523-1755.1998.00159.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Double immunostaining of a 51-year-old male patient with anti-tryptase antibody (a), and anti-basic fibroblast growth factor (bFGF) (b). Tryptase positive mast cells are scattered in fibrous interstitium and positive for bFGF in this field except one (arrow) (×250). Kidney International 1998 54, 1675-1683DOI: (10.1046/j.1523-1755.1998.00159.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 5 The same area from a 25-year-old female with IgA nephritis is stained with UCHL-1 (a), and anti-tryptase monoclonal antibody (b). (a) UCHL-1 is positive where lymphocytes accumulated (arrow). (b) Tryptase positive cells are scattered in the interstitium. No positive cells are found in glomeruli (small arrows). In this field, the average number of UCHL-1 and tryptase positive cells in the interstitium is 344 and 42/mm2, respectively (×150). Kidney International 1998 54, 1675-1683DOI: (10.1046/j.1523-1755.1998.00159.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 6 Correlation between the number of cells and the 24-hour creatinine clearance. y = - 0.870x + 98.383; r = 0.650; P < 0.05. Kidney International 1998 54, 1675-1683DOI: (10.1046/j.1523-1755.1998.00159.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 7 Electron micrograph of a 44-year-old male with IgA nephritis. A fibroblast (F), lymphocyte (L), and mast cell (M) are associated and attached by processes (arrows) (×6000). Kidney International 1998 54, 1675-1683DOI: (10.1046/j.1523-1755.1998.00159.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 8 Specific granules in a mast cell are selectively labeled with 10nm gold particles (×34,000). Kidney International 1998 54, 1675-1683DOI: (10.1046/j.1523-1755.1998.00159.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1675-1683DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1675-1683DOI: (10.1046/j.1523-1755.1998.00159.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1675-1683DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1675-1683DOI: (10.1046/j.1523-1755.1998.00159.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1675-1683DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1675-1683DOI: (10.1046/j.1523-1755.1998.00159.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1675-1683DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1675-1683DOI: (10.1046/j.1523-1755.1998.00159.x) Copyright © 1998 International Society of Nephrology Terms and Conditions