M. Korva, A. Saksida, N. Kejzar, C. Schmaljohn, T. Avŝiĉ-Zupanc

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Presentation transcript:

Viral load and immune response dynamics in patients with haemorrhagic fever with renal syndrome M. Korva, A. Saksida, N. Kejzar, C. Schmaljohn, T. Avŝiĉ-Zupanc Clinical Microbiology and Infection Volume 19, Issue 8, Pages e358-e366 (August 2013) DOI: 10.1111/1469-0691.12218 Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Mean kinetic of viral load in patients infected with Dobrava virus DOBV (left) and Puumala virus PUUV (right). In the lower two figures the kinetics of viral load in a single patient infected with DOBV (left) and PUUV (right) is presented. Clinical Microbiology and Infection 2013 19, e358-e366DOI: (10.1111/1469-0691.12218) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 IgM and IgG antibody response against Dobrava virus (DOBV) and Puumala virus(PUUV) infection in plasma samples of haemorrhagic fever with renal syndrome(HFRS) patients. Clinical Microbiology and Infection 2013 19, e358-e366DOI: (10.1111/1469-0691.12218) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3 Shape of mean IgG response for the regression model where the day of illness and viral load were treated as non-linear. The scale on the y-axis corresponds to the fifteenth day of illness. Clinical Microbiology and Infection 2013 19, e358-e366DOI: (10.1111/1469-0691.12218) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 4 Mean dynamic of IL-10, TNF-α, IFN-γ and IL-12 in plasma samples of haemorrhagic fever with renal syndrome(HFRS) patients during the entire hospitalization time. The red line represents cytokine concentrations measured in healthy blood donors in Slovenia. Clinical Microbiology and Infection 2013 19, e358-e366DOI: (10.1111/1469-0691.12218) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 5 The shape of the mean response of IL-10 for the regression model where the day of illness was treated as a linear and log viral load as a non-linear effect. The scale on the y-axis corresponds to the tenth day of illness. Clinical Microbiology and Infection 2013 19, e358-e366DOI: (10.1111/1469-0691.12218) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions