Vascular Endothelial Growth Factor and Epidermal Growth Factor Signaling Pathways as Therapeutic Targets for Colorectal Cancer Thomas Winder, Heinz–Josef.

Slides:

Advertisements

Similar presentations

Gene Transcription G0G0 G1G1 Priming S G2G2 M Cell Cell Cycle Growth Factors + Growth Factors & Cell Cycle Receptors.

Advertisements

Hepatic Vascular Endothelial Growth Factor Regulates Recruitment of Rat Liver Sinusoidal Endothelial Cell Progenitor Cells Lin Wang, Xiangdong Wang, Lei.

Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non- small cell lung cancer: Focus on epidermal growth factor receptor.

Novel targets in gastric and esophageal cancer

Silvestri Gerard A. , MD, FCCP, Rivera M. Patricia , MD, FCCP CHEST

Figure 1. Resistance mechanism against first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). (A) Mutations in the EGFR.

Trans. Vis. Sci. Tech ;5(2):10. doi: /tvst Figure Legend:

Arne R. M. van der Bilt, Elisabeth G. E

Volume 76, Issue 9, Pages (November 2009)

Volume 149, Issue 4, Pages (October 2015)

Louise E. Glover, Sean P. Colgan Gastroenterology

Volume 149, Issue 4, Pages (October 2015)

Treatment of Glioma in the 21st Century: An Exciting Decade of Postsurgical Treatment Advances in the Molecular Era Joon H. Uhm, MD, Alyx B. Porter,

Miriam Marqués, Francisco X. Real European Urology

HER2/HER3 heterodimers in prostate cancer

Christoph Lübbert, Babett Holler Gastroenterology

Somatostatin, Estrogen, and Polycystic Liver Disease

c-Kit as a Novel Potential Therapeutic Target in Colorectal Cancer

Dan Gordon Gastroenterology Volume 114, Issue 4, (April 1998)

Figure 1 A schematic representation of the HER2 signalling pathway

Is HCV Infection a Neurologic Disorder?

Volume 56, Issue 3, Pages (March 2012)

Chasing Therapeutic Targets in Thymic Malignancies: Finding Needles in the Haystack to Frame a Comprehensive Canvas? Nicolas Girard, MD Journal of Thoracic.

Personalizing Therapy for Colorectal Cancer

Figure 2 Oestrogen receptor signalling pathways

Biology and Clinical Applications of Pancreatic Cancer Stem Cells

Xiaolan Yao, Samuel Bouyain Structure

Suppressing NFAT Increases VEGF Signaling in Hemangiomas

Personalizing Therapy for Colorectal Cancer

GLP-1–Based Therapies: The Dilemma of Uncertainty

Volume 134, Issue 5, Pages (May 2008)

Stealing VEGF from Thy Neighbor

Caught in the Akt: Regulation of Wnt Signaling in the Intestine

Jing Zhang, Thomas M. Roberts, Ramesh A. Shivdasani Gastroenterology

VEGF-B Improves Metabolic Health through Vascular Pruning of Fat

Volume 150, Issue 4, Pages (April 2016)

Toru Furukawa Clinical Gastroenterology and Hepatology

Apoptosis-targeted therapies for cancer

A. Craig Lockhart, Mace L. Rothenberg, Jordan D. Berlin

Volume 22, Issue 6, Pages (December 2012)

Colon Cancer: An Update and Future Directions

Volume 137, Issue 1, Pages (July 2009)

Vascular Endothelial Growth Factor (VEGF) Pathway

FGFR Signaling as a Target for Lung Cancer Therapy

Understanding the Importance of Smart Drugs in Renal Cell Carcinoma

Volume 76, Issue 9, Pages (November 2009)

Characterizing the Killer Colorectal Carcinomas

Figure 1 The VEGF family of growth factors

Barbara Jung, Jonas J. Staudacher, Daniel Beauchamp Gastroenterology

VEGF-B Improves Metabolic Health through Vascular Pruning of Fat

Covering the Cover Gastroenterology

Targeting Smads to Restore Transforming Growth Factor-β Signaling and Regulatory T- Cell Function in Inflammatory Bowel Disease Deanna D. Nguyen, Scott.

Targeting STAT3 in hepatocellular carcinoma: Sorafenib again…

Volume 73, Issue 1, Pages 5-7 (January 2008)

Volume 139, Issue 2, Pages e3 (August 2010)

Coffee and Colorectal Cancer: Grounds for Prevention?

Volume 148, Issue 3, Pages (March 2015)

SRC and STAT Pathways Journal of Thoracic Oncology

Yan Feng, MD, Praveena S. Thiagarajan, PhD, Patrick C. Ma, MD

Apoptosis-targeted therapies for cancer

The Dawning of a New Editorial Board for Gastroenterology

mTOR Regulation by JNK: Rescuing the Starving Intestinal Cancer Cell?

The VEGF Family, the Inside Story

Jack L. Arbiser Journal of Investigative Dermatology

Volume 156, Issue 4, Pages (March 2019)

Platelet-derived growth factor (PDGF) signalling pathway.

Volume 155, Issue 6, Pages (December 2018)

Volume 138, Issue 6, Pages (May 2010)

The new kid on the block(ade) of the IGF-1 receptor

Volume 1, Issue 3, Pages (April 2002)

Presentation transcript:

Vascular Endothelial Growth Factor and Epidermal Growth Factor Signaling Pathways as Therapeutic Targets for Colorectal Cancer Thomas Winder, Heinz–Josef Lenz Gastroenterology Volume 138, Issue 6, Pages 2163-2176 (May 2010) DOI: 10.1053/j.gastro.2010.02.005 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 VEGF family members and receptors. The VEGF family comprises 5 VEGF glycoproteins (VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E) and placenta growth factors (PlGF) 1 and 2. The best characterized of the VEGF ligands, VEGF-A, has different isoforms generated by alternate splicing. The primary effects of these ligands are mediated through binding to the VEGFR tyrosine kinases (TK) (VEGF-R1, VEGF-R2, VEGF-R3) and neuropilins 1 and 2, which function as coreceptors for VEGF binding. Gastroenterology 2010 138, 2163-2176DOI: (10.1053/j.gastro.2010.02.005) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 EGFR signaling. EGFR binding to ligands and receptor dimerization activate the Ras-MAPK, PI3K-AKT, and STAT signal transduction pathways. These signaling pathways activate transcription factors that regulate genes whose products control cell functions such as survival, proliferation, angiogenesis, invasion, and metastasis. Gastroenterology 2010 138, 2163-2176DOI: (10.1053/j.gastro.2010.02.005) Copyright © 2010 AGA Institute Terms and Conditions

Thomas Winder* Gastroenterology 2010 138, 2163-2176DOI: (10.1053/j.gastro.2010.02.005) Copyright © 2010 AGA Institute Terms and Conditions

Heinz–Josef Lenz*,‡ Gastroenterology 2010 138, 2163-2176DOI: (10.1053/j.gastro.2010.02.005) Copyright © 2010 AGA Institute Terms and Conditions