Reproductive and metabolic determinants of granulosa cell dysfunction in normal-weight women with polycystic ovary syndrome Annie A. Guedikian, B.S.,

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Presentation transcript:

Reproductive and metabolic determinants of granulosa cell dysfunction in normal-weight women with polycystic ovary syndrome Annie A. Guedikian, B.S., Alexandria Y. Lee, Tristan R. Grogan, M.S., David H. Abbott, Ph.D., Karla Largaespada, B.S., Gregorio D. Chazenbalk, Ph.D., Daniel A. Dumesic, M.D. Fertility and Sterility Volume 109, Issue 3, Pages 508-515 (March 2018) DOI: 10.1016/j.fertnstert.2017.11.017 Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Twenty-four-hour AUC determinations for serum E2 and FSH responses to 150 IU rhFSH IV infusion. The serum E2 response to rhFSH was significantly greater in women with PCOS (n = 7) than in BMI- and age-matched control (n = 13) women (A), despite similar serum FSH responses to rhFSH injection in both female groups (B). The initial rise of serum E2 in all women occurred 4–6 hours after rhFSH injection, with the subsequent rise thereafter to maximal serum E2 levels at 16 hours being greater in women with PCOS than in the control women (C). Serum FSH levels rose to maximal levels approximately 6 hours after 150 IU rhFSH IV infusion and then declined from these levels thereafter (D). *P=.009 versus BMI- and age-matched controls (mean ± SEM). Fertility and Sterility 2018 109, 508-515DOI: (10.1016/j.fertnstert.2017.11.017) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Serum E2 response to rhFSH positively correlated with (A) percent android fat, (B) serum total T level, and (C) log AFN in all women combined (13 BMI- and age-matched controls [open circles], seven PCOS [dark circles]: total, 20 women). Fertility and Sterility 2018 109, 508-515DOI: (10.1016/j.fertnstert.2017.11.017) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Serum AMH levels positively correlated with (A) percent android fat; serum levels of (B) total T, (C) free T, (D) A4, and (E) LH, as well as (F) log AFN in all women combined (13 BMI- and age-matched controls [open circles], six PCOS [dark circles]: total, 19 women). Fertility and Sterility 2018 109, 508-515DOI: (10.1016/j.fertnstert.2017.11.017) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions