Michael A. den Bakker, MD, PhD, Anja C

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Presentation transcript:

Histologic Classification of Thymoma: A Practical Guide for Routine Cases Michael A. den Bakker, MD, PhD, Anja C. Roden, MD, Alexander Marx, MD, Mirella Marino, MD Journal of Thoracic Oncology Volume 9, Issue 9, Pages S125-S130 (September 2014) DOI: 10.1097/JTO.0000000000000297 Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Main thymoma subtypes. A–D, Type A thymoma: (A) low power, (B) medium power H&E stain, (C) cytokeratin stain, (D) p63 stain. E–I, Type AB thymoma: (E) low power overview, (F) “A” area composed of spindle cells devoid of lymphocytes, (G) “B” area with moderately dense lymphocyte population; (H, I) cytokeratin (H) and TdT (I) stain of adjacent “A” and “B” areas. J–M, Type B1 thymoma: low (J) and high (K) power H&E stain; cytokeratin (L) and TdT (M) stain, with sparing of a medullary island. Note residual normal thymic tissue in (J). N–Q, Type B2 thymoma: low (N) and high (O) power H&E stain; cytokeratin (P) and TdT (Q) stain. R–U, Type B3 thymoma: low (R) and high (S) power H&E stain; cytokeratin (T) and TdT (U) stain. Journal of Thoracic Oncology 2014 9, S125-S130DOI: (10.1097/JTO.0000000000000297) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Flowchart for initial hematoxylin and eosin-based subtyping of thymoma; final subtyping must take all criteria into account as described in the text. Journal of Thoracic Oncology 2014 9, S125-S130DOI: (10.1097/JTO.0000000000000297) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions