Volume 11, Issue 1, Pages (January 2014)

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Volume 11, Issue 1, Pages 46-52 (January 2014) Candidate gene approach to identifying rare genetic variants associated with lone atrial fibrillation Peter Weeke, MD, Babar Parvez, MD, Marcia Blair, MS, Laura Short, MS, Christie Ingram, BS, Gayle Kucera, RN, Tanya Stubblefield, RN, Dan M. Roden, MD, FHRS, Dawood Darbar, MD, FHRS Heart Rhythm Volume 11, Issue 1, Pages 46-52 (January 2014) DOI: 10.1016/j.hrthm.2013.10.025 Copyright © 2014 Heart Rhythm Society Terms and Conditions

Figure 1 Flow chart identifying rare variants in screened candidate genes. AAC = amino acid coding; AF = atrial fibrillation; ESP6500 = Exome Sequencing Project of 6500 individuals using the reported minor allele frequency (MAF) for 4300 European Americans (EA). Heart Rhythm 2014 11, 46-52DOI: (10.1016/j.hrthm.2013.10.025) Copyright © 2014 Heart Rhythm Society Terms and Conditions

Figure 2 Pedigrees of families with evidence of very rare amino acid coding (AAC) variants co-segregating with lone atrial fibrillation (AF). A variant was designated to have evidence of co-segregation with AF if ≥1 first-degree relative was affected with AF and also carried the same very rare variant as the proband. Heart Rhythm 2014 11, 46-52DOI: (10.1016/j.hrthm.2013.10.025) Copyright © 2014 Heart Rhythm Society Terms and Conditions