Reciprocal functions of hepatocyte growth factor and transforming growth factor-β1 in the progression of renal diseases: A role for CD44?  Sandrine Florquin, Kasper M.A. Rouschop  Kidney International  Volume 64, Pages S15-S20 (October 2003) DOI: 10.1046/j.1523-1755.64.s86.4.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Pathophysiologic mechanisms of renal damage. Abbreviations are: AT, angiotensin; PDGF, platelet-derived growth factor; VEGF, vascular endothelial growth factor; TECs, tubular epithelial cells; T, T lymphocyte; Mφ, macrophage; ECM, extracellular matrix. Kidney International 2003 64, S15-S20DOI: (10.1046/j.1523-1755.64.s86.4.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 The reciprocal effects of transforming growth factor-β1 (TGF-β1) and hepatocyte growth factor (HGF) in the cascade of tubulointerstitial damage. Black arrows, inhibitory actions; gray arrows, controversial actions; open arrows, stimulatory actions. Abbreviations are: TECs, tubular epithelial cells; ECM, extracellular matrix; MMP, matrix metalloproteinase; TIMP, tissue inhibitors of matrix metalloproteinase. Kidney International 2003 64, S15-S20DOI: (10.1046/j.1523-1755.64.s86.4.x) Copyright © 2003 International Society of Nephrology Terms and Conditions