Induced pluripotent stem cells: From Nobel Prizes to clinical applications  S. Tamir Rashid, Graeme J.M. Alexander  Journal of Hepatology  Volume 58, Issue 3, Pages 625-629 (March 2013) DOI: 10.1016/j.jhep.2012.10.026 Copyright © 2012 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Derivation of pluripotent stem cells. Pluripotent stem cells, possessing the ability to form any cell type of the human body, can be created using in vitro fertilisation (Steptoe and Edwards), somatic cell nuclear transfer (Gurdon), and transcription factor overexpression (Yamanaka). Journal of Hepatology 2013 58, 625-629DOI: (10.1016/j.jhep.2012.10.026) Copyright © 2012 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Using iPSCs for human therapy. Patient specific skin samples are firstly reprogrammed into iPSCs. Genetic diseases could then be treated by editing the genomes of iPSCS, differentiating them into target adult cells, and finally transplanting the corrected cells back into the original patient. Journal of Hepatology 2013 58, 625-629DOI: (10.1016/j.jhep.2012.10.026) Copyright © 2012 European Association for the Study of the Liver Terms and Conditions