In and out of the Replication Factory

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In and out of the Replication Factory Peter Meister, Angela Taddei, Susan M. Gasser Cell Volume 125, Issue 7, Pages 1233-1235 (June 2006) DOI: 10.1016/j.cell.2006.06.014 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 DNA Replication in Factories (A) Clustered replication forks may promote coordinated decatenation of DNA during replication. Synchronous initiation at adjacent replication forks and the extrusion of newly synthesized, decatenated DNA may occur within a replication factory. The loading of cohesion rings holds sister chromatids together and allows pairing during decatenation. (B) Firing of adjacent replication origins can help to rescue stalled replication forks. If adjacent replication origins fire at the same time, the stalling of one can be easily remedied by the progression of the neighboring replication fork. Cell 2006 125, 1233-1235DOI: (10.1016/j.cell.2006.06.014) Copyright © 2006 Elsevier Inc. Terms and Conditions