Antiviral Strategies: Building a Better Defense

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Antiviral Strategies: Building a Better Defense   Cell  Volume 153, Issue 4, (May 2013) DOI: 10.1016/j.cell.2013.04.039 Copyright © 2013 Terms and Conditions

“Enveloped” (left) and nonenveloped (right) hepatitis A virus particles released from infected hepatoma cell cultures. Image courtesy of The University of North Carolina at Chapel Hill. Cell 2013 153, DOI: (10.1016/j.cell.2013.04.039) Copyright © 2013 Terms and Conditions

Highly heterogeneous proteins like ABCE1 may be part of “next generation” drug targets, provided the implicated subset can be distinguished, as done by Lingappa et al. for rabies capsid assembly (red box). Image courtesy of U.F. Lingappa. Cell 2013 153, DOI: (10.1016/j.cell.2013.04.039) Copyright © 2013 Terms and Conditions

A cryoelectron microscopy reconstruction of the high-temperature dengue virus “bumpy” surface, colored according to the radial distance of the surface from the viral center. Image courtesy of M. Rossmann. Cell 2013 153, DOI: (10.1016/j.cell.2013.04.039) Copyright © 2013 Terms and Conditions

A cartoon of a viral fitness landscape inferred by the approach of Ferguson et al.; Image courtesy of A. Chakraborty. Cell 2013 153, DOI: (10.1016/j.cell.2013.04.039) Copyright © 2013 Terms and Conditions