By JERLIN G. Research Scholar, Department of Physics. DRUG DELIVERY SYSTEM By JERLIN G. Research Scholar, Department of Physics.

INTRODUCTION Cellular delivery involving the transfer of various drugs and bio-active molecules (peptides, proteins and DNAs, etc.) through the cell membrane. Drug delivery systems control the rate at which a drug is released and the location in the body where it is released.  Some systems can control both.

Steps involved in drug delivery 1.Surface functionalisation 2.Loading of biomolecules 3.Transport of nanohybrid 4.Interaction of nanohybrids with cell membrane 5.Endocytosis pathways of nanohybrids 6.Rupture of endosomal compartment 7.Release of drug

A: inorganic nanoparticle; B: organically modified inorganic nanoparticle; C: nanohybrid with DNA loaded; D: nanohybrid-cell electrostatic attraction; E: cell recognition of nanohybrid via ‘Y’ (red) and ‘V’ (black) interconnection between the loaded protein and membrane protein; F: deformation of cell membrane to take up the nanohybrid; G: nanohybrid endocytosed into cell; H: nanohybrid-endosome breaking down; I: DNA released after endosomal breaking

Applications Cancer, AIDS treatment Antibiotics Pulmonary infections

Advantages Drug targeting of individual tissues Cells & cellular receptors and hence suitable for gene and vaccine delivery Controlled delivery drug devices Less toxic as well as inexpensive

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