(M9) WPDxGxP (M8) TxxD FWxMxW (M5) (M2) (M1) IAxQGP (M4) QTxx (M10)

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(M9) WPDxGxP (M8) TxxD FWxMxW (M5) (M2) (M1) IAxQGP (M4) QTxx (M10) Core structures within the PTP domain are highly conserved and surface loops between secondary structure elements are least conserved PxxV HCSAGxGRTG (M9) WPDxGxP (M8) IVMxT (M6) KCxxYWP (M7) TxxD FWxMxW (M5) DxxRVxL (M2) DYINA (M3) NxxKNRY (M1) IAxQGP (M4) QTxx QYxF (M10) Ribbon diagram indicating the position of conserved motifs (M1-M10) within the tertiary structure of PTP1B (blue - most conserved; red - least conserved). http://ptp.cshl.edu & http://science.novonordisk.com/ptp Andersen et al Mol. Cell. Biol. 2001