Effect of muscle weakness and joint inflammation on the onset and progression of osteoarthritis in the rabbit knee C. Egloff, A. Sawatsky, T. Leonard,

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Effect of muscle weakness and joint inflammation on the onset and progression of osteoarthritis in the rabbit knee C. Egloff, A. Sawatsky, T. Leonard, D.A. Hart, V. Valderrabano, W. Herzog Osteoarthritis and Cartilage Volume 22, Issue 11, Pages 1886-1893 (November 2014) DOI: 10.1016/j.joca.2014.07.026 Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Mean (95% CI) of total wet muscle mass (VL, Vastus medialis, Rectus femoris and Vastus intermedius) for the experimental and control limbs for each intervention group after 12 weeks. Bars marked with * show significant differences in the total muscle mass between experimental and control limb. Osteoarthritis and Cartilage 2014 22, 1886-1893DOI: (10.1016/j.joca.2014.07.026) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Mean (95% CI) of joint diameter (mm) between experimental and control limbs across intervention groups. Bars marked with * show significant differences in the joint diameter between experimental and control limbs. Osteoarthritis and Cartilage 2014 22, 1886-1893DOI: (10.1016/j.joca.2014.07.026) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Mean (95% CI) OARSI scores for the experimental and control limbs for each intervention group after 12 weeks according to the anatomical region. Bars marked with * show significant differences in the OARSI score between experimental and control limb. Osteoarthritis and Cartilage 2014 22, 1886-1893DOI: (10.1016/j.joca.2014.07.026) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Mean (95% CI) of OARSI scores of the synovium for the experimental and control limbs for each intervention group after 12 weeks. Bars marked with * show significant differences in the OARSI score between experimental and control limbs. Osteoarthritis and Cartilage 2014 22, 1886-1893DOI: (10.1016/j.joca.2014.07.026) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Microscopic analysis of synovium sample (20× magnification). A: Synovial probe of group 1 animals (VL transection) with OARSI score 2. B: Synovial example of group 2 (BTX-A injection) showing mild synovial reaction with an OARSI score of 4. C: Example of group 4 (BTX-A/Carrageenan) showing severe synovial inflammatory reaction with an OARSI score of 11. D: Synovial example of group 3 (Carrageenan) with severe inflammatory reaction with an OARSI score of 16. Osteoarthritis and Cartilage 2014 22, 1886-1893DOI: (10.1016/j.joca.2014.07.026) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 Microscopic images of three different animals in 5× magnification (A, C, E) and 20× magnification (B, D, F). All histological slides are examples from the femoral condyle. A, B: contralateral control side from a specimen of the BTX-group showing an OARSI score of 3 (normal). C, D: experimental side from a specimen of the BTX/carrageenan-group showing an OARSI score of 12 (moderate OA) E, F: experimental side from a specimen of the BTX-group showing an OARSI score of 18 (severe OA). Osteoarthritis and Cartilage 2014 22, 1886-1893DOI: (10.1016/j.joca.2014.07.026) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions