Volume 60, Issue 1, Pages (July 2001)

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Presentation transcript:

Volume 60, Issue 1, Pages 167-172 (July 2001) Role of stem cell factor and mast cells in the progression of chronic glomerulonephritides1 Ahmed F. El-Koraie, Nahed M. Baddour, Ahmed G. Adam, Essam H. El Kashef, A. Meguid El Nahas, M.D. Kidney International Volume 60, Issue 1, Pages 167-172 (July 2001) DOI: 10.1046/j.1523-1755.2001.00783.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 (A) Photomicrograph showing the immunostain for mast cell tryptase (MCT) in a diseased cell (×200). (B) Photomicrograph showing mast cells (MC) in the interstitium of a diseased kidney stained with toluidine blue (×200). Kidney International 2001 60, 167-172DOI: (10.1046/j.1523-1755.2001.00783.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 (A) Photomicrograph showing MCT+ cells in the renal interstitium. (B) Periglomerular distribution of MC (×400). (C) Distribution of α-smooth muscle actin (α-SMA) + cells in a diseased kidney (×200). (D) CD68+ cells among interstitial infiltrates (×200). Kidney International 2001 60, 167-172DOI: (10.1046/j.1523-1755.2001.00783.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 (A) Photomicrograph showing immunostaining for stem cell factor (SCF) within a glomerular parietal epithelial cell of a diseased kidney (×400). (B) Immunostaining for SCF within tubular cells of a diseased kidney (×400). Kidney International 2001 60, 167-172DOI: (10.1046/j.1523-1755.2001.00783.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 4 (A) Photomicrograph showing double staining (brown color) for SCF and CD68+ macrophages within an interstitial cell in a diseased kidney (×400). (B) Double staining (brown color) for SCF and MCT within an interstitial cell in a diseased kidney (×400). Kidney International 2001 60, 167-172DOI: (10.1046/j.1523-1755.2001.00783.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 5 (A) Photomicrograph showing few interstitial cells stained for C-kit in a diseased kidney (×400). (B) Photomicrograph showing an interstitial cell stained for C-kit with a membrane-bound pattern of immunostaining (×400). Kidney International 2001 60, 167-172DOI: (10.1046/j.1523-1755.2001.00783.x) Copyright © 2001 International Society of Nephrology Terms and Conditions