Regulatory CD4+ T cell–derived IL-10 is important for B cell differentiation and the GC response. Regulatory CD4+ T cell–derived IL-10 is important for.

Slides:

Advertisements

Similar presentations

High-dimensional analysis of lymphoid CD4+ T cells identified distinct TFH cell subsets in HIV+ patients and HCs. High-dimensional analysis of lymphoid.

Advertisements

Dominant IL-21 expression in TFH cells correlate with B cell pathology in HIV-infected LNs. Dominant IL-21 expression in TFH cells correlate with B cell.

GC TFH cells exhibit HIV antigen–driven clonal expansion and selection

Identification of combination treatment–responsive dysfunctional tumor-infiltrating CD8+ T cell population. Identification of combination treatment–responsive.

Fibroblast activation in WT and NFATc2-deficient mice.

CD8α+ DC-deficient mice are highly susceptible to Lm infection in the absence of CD169+ macrophages. CD8α+ DC-deficient mice are highly susceptible to.

NFATc2-deficient mice do not eliminate skin C. albicans infections.

Antitumor effect of local cancer immunotherapy treatment toward distant B16F10 tumors. Antitumor effect of local cancer immunotherapy treatment toward.

CXCR5+/+ TFH cells are dispensable for maintenance of the LCMV-specific antibody response. CXCR5+/+ TFH cells are dispensable for maintenance of the LCMV-specific.

Specific depletion of CD4-DTR–derived CD4 T cells.

Longitudinal analysis of ZIKV E–specific memory B cell responses in the DENV-experienced donors. Longitudinal analysis of ZIKV E–specific memory B cell.

Core 2 O-glycan synthesis is stimulated by IL-15 signaling.

Memory CD8+ T cells that become terminally differentiated by multiple antigen encounters lose core 2 O-glycan synthesis activity. Memory CD8+ T cells that.

CD169+ macrophages mediate Lm translocation to the splenic T cell zones. CD169+ macrophages mediate Lm translocation to the splenic T cell zones. (A) Confocal.

LV activation of DCs and subsequent CD8+ T cell priming are dependent on STING and cGAS but not on MyD88, TRIF, or MAVS. LV activation of DCs and subsequent.

Human PBMC-derived MERS-CoV–specific T cells are multifunctional.

Cytosolic entry of Lm required for CD8α+ DC recruitment.

Virus-specific T cell responses are detected in all MERS survivors.

NRP1-expressing myeloid cells influence adipocyte hypertrophy, development of fatty liver, and CLSs. NRP1-expressing myeloid cells influence adipocyte.

VH usage of cross-reactive B cells induced by H5N1 or H7N9 vaccination

Reduced FOXO1 expression in GC B cells from mice lacking regulatory CD4+ T cell–derived IL-10. Reduced FOXO1 expression in GC B cells from mice lacking.

Macrophage-resident NRP1 promotes FA uptake.

NRP1-expressing myeloid cells contribute to adipose tissue vascularization. NRP1-expressing myeloid cells contribute to adipose tissue vascularization.

Molecular and functional characterization of antibodies from PfCSP-reactive memory B cells and plasmablasts. Molecular and functional characterization.

MP cells can mediate resistance in infectious models that induce TH1-type immunity. MP cells can mediate resistance in infectious models that induce TH1-type.

Tfr cells robustly secrete IL-10 after acute viral infection.

Tfr cell–derived IL-10 is important for B cell differentiation and the GC response. Tfr cell–derived IL-10 is important for B cell differentiation and.

Characterization of the light-responsive transdermal MNs.

Differential expression of TRM markers by donor- and recipient-derived T cells with time. Differential expression of TRM markers by donor- and recipient-derived.

Macrophage-resident NRP1 mitigates cytokine release and proinflammatory polarization. Macrophage-resident NRP1 mitigates cytokine release and proinflammatory.

Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells. Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells.

Blood Tfr cells show expression of follicular and regulatory markers.

Persistent TCR–pMHC-I signaling drives the formation and maintenance of exhausted-like TRM cells. Persistent TCR–pMHC-I signaling drives the formation.

T-bethi MP cells produce IFN-γ in response to IL-12.

IL-10R-deficient macrophages secrete IL-23, inducing IL-22 secretion by ILC3 and TH17 cells. IL-10R-deficient macrophages secrete IL-23, inducing IL-22.

TCR signaling is required for exhausted-like TRM cell formation and maintenance. TCR signaling is required for exhausted-like TRM cell formation and maintenance.

Blood Tfr cells are lymphoid tissue–derived Tfr precursors.

Neutrophil depletion ameliorates colitis in Cx3cr1cre:Il10rafl/fl BM chimeras. Neutrophil depletion ameliorates colitis in Cx3cr1cre:Il10rafl/fl BM chimeras.

NCMs regulate T cell survival in TLOs via PD-L1.

PD-L1 selectively marks circulating NCMs.

CXCR5+/+ TFH cells are essential for the generation of LCMV-neutralizing antibodies and clearance of a persistent LCMV infection. CXCR5+/+ TFH cells are.

Tumor control by necroptotic cells requires BATF3+cDC1 and CD8+leukocytes. Tumor control by necroptotic cells requires BATF3+cDC1 and CD8+leukocytes. (A)

Variable number of CD4-CTL precursors across donors.

CD169+ macrophages mediate the transport of bacteria to T cell zones by trans-infecting CD8α+ DCs. CD169+ macrophages mediate the transport of bacteria.

CD4-CTL precursor cells in the TEMRA subset.

Evaluation of multidonor class Ig sequences obtained from H5N1 and H7N9 vaccinated donors. Evaluation of multidonor class Ig sequences obtained from H5N1.

Slc7a5 deficiency stimulates osteoclastogenesis in vitro.

Shared phenotype of CD4+CLA+CD103+ T cells from human blood and skin.

Blood Tfr cells do not show specialized humoral regulatory capacity.

RORα deficiency in Tregs results in exaggerated skin inflammation in response to EC sensitization. RORα deficiency in Tregs results in exaggerated skin.

CD25 surface expression and TCR signal strength predict T helper differentiation and memory potential of early effector T cells in vivo. CD25 surface expression.

AEGIS autonomous targeting process.

Human Tfr cells do not express CD25.

CD4+ memory T cells derived from either CD25hi or CD25lo effector cells respond robustly to secondary challenge. CD4+ memory T cells derived from either.

CD25 expression predicts effector and memory differentiation.

Binding characteristics of mAbs isolated from plasmablasts during acute ZIKV infection. Binding characteristics of mAbs isolated from plasmablasts during.

Impact of FRC-specific Myd88 ablation on omental FALC organization.

Fibroblast activation in WT and NFATc2-deficient mice.

Expansion of omental FRCs and FALC remodeling after intraperitoneal exposure to bacterial antigen. Expansion of omental FRCs and FALC remodeling after.

Lin28b promotes the positive selection of CD5+ ImmB cells in neonatal mice. Lin28b promotes the positive selection of CD5+ ImmB cells in neonatal mice.

IL-9–expressing TH cells are highly enriched in CCR4+/CCR8+ effector memory TH cells. IL-9–expressing THcells are highly enriched in CCR4+/CCR8+effector.

Acute circadian disruption alters ILC3 cytokine secretion.

REV-ERBα deficiency reduces frequency and number of NKp46+ ILC3s.

Meningeal γδ T cells are biased toward IL-17 production.

Fetal-derived γδ T cells infiltrate the meninges from birth.

T cell–derived IL-13 is essential for the inception of AHR.

Fig. 6 tlr2 is necessary for SASP activation in vivo.

Neutralizing activity of mAbs isolated from plasmablasts during acute ZIKV infection in DENV-experienced donors. Neutralizing activity of mAbs isolated.

Bb monocolonization enhances Treg population in the cLP.

CCR6 is dispensable for expansion of innate TCRαβ+ cells in oral candidiasis. CCR6 is dispensable for expansion of innate TCRαβ+ cells in oral candidiasis.

Presentation transcript:

Regulatory CD4+ T cell–derived IL-10 is important for B cell differentiation and the GC response. Regulatory CD4+ T cell–derived IL-10 is important for B cell differentiation and the GC response. Analysis of the B cell response in Il10f/f and Il10f/fFoxp3-Cre mice 15 days after LCMV infection. (A) Top: Representative plots of the B cell responses in Il10f/f or Il10f/fFoxp3-Cre mice. Bottom: Frequency and number of cells as indicated by the gates shown above. (B) Representative confocal images of the GC from Il10f/f or Il10f/fFoxp3-Cre mice. Right: GC sizes as measured by ImageJ. The sections were taken from four mice of each genotype. Scale bar, 100 μm. (C) Left: Frequency of plasmablasts and memory B cells defined by the expression of surface markers. Right: Absolute numbers of plasma cells and memory B cells. (D) Enzyme-linked immunosorbent assay quantification of LCMV-specific IgG2a and IgG1 antibody levels, indicated by arbitrary units (a.u.). All the analyses of the GC response were performed 15 days after acute LCMV Armstrong infection. n.s., not significant. (E) Enzyme-linked immunospot quantification of the number of LCMV-specific IgG2a and IgG1 memory B cells. All the analyses of the GC response were performed 60 days after acute LCMV Armstrong infection. Statistical analyses were performed using unpaired two-tailed Student’s t test (*P < 0.05; **P < 0.01; ***P < 0.001). Data for (A) to (C) are from one experiment representative of three experiments with three to five mice per group carried out 15 days after LCMV Armstrong infection and from four experiments with three to five mice per group carried out 12 days after LCMV Armstrong infection. Data for (D) are pooled from two experiments carried out 12 or 15 days after infection. Data for (E) are pooled from two experiments with five to seven mice per group carried out 60 days after infection. Brian J. Laidlaw et al. Sci. Immunol. 2017;2:eaan4767 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works