Neurobehavioural effects of developmental toxicity Dr Philippe Grandjean, MD, Philip J Landrigan, MD  The Lancet Neurology  Volume 13, Issue 3, Pages 330-338 (March 2014) DOI: 10.1016/S1474-4422(13)70278-3 Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 Effect of neurotoxicants during early brain development Exposures in early life to neurotoxic chemicals can cause a wide range of adverse effects on brain development and maturation that can manifest as functional impairments or disease at any point in the human lifespan, from early infancy to very old age. The Lancet Neurology 2014 13, 330-338DOI: (10.1016/S1474-4422(13)70278-3) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 2 Functional MRI scans show abnormal activation in the brain Average activation during finger tapping with the left hand in three adolescents with increased prenatal methylmercury exposure (A) and three control adolescents (B). The control participants activate the premotor and motor cortices on the right, whereas participants exposed to methylmercury activate these areas bilaterally.31 The Lancet Neurology 2014 13, 330-338DOI: (10.1016/S1474-4422(13)70278-3) Copyright © 2014 Elsevier Ltd Terms and Conditions