Renal vascular sclerosis is associated with inherited thrombophilias

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Renal vascular sclerosis is associated with inherited thrombophilias R.L. Goforth, H. Rennke, S. Sethi Kidney International Volume 70, Issue 4, Pages 743-750 (August 2006) DOI: 10.1038/sj.ki.5001551 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Typical vascular lesion. (a) PAS-stained section showing an artery with intimal sclerosis, myointimal hyperplasia, and thickening of the wall. (b) Electron microscopy showing subendothelial expansion with cellular elements and new glomerular basement formation in the absence of electron dense deposits, resulting in double contours (arrows) (original magnification × 1850). Kidney International 2006 70, 743-750DOI: (10.1038/sj.ki.5001551) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 2 Identification of prothrombin, factor V, and MTHFR genotype. (a) Wild-type reaction for prothrombin and factor V. (b) Mutant reaction for prothrombin and factor V. In (a and b), lane 1 is a 100bp ladder, lanes 2 through 5 are experimental patient samples (lane 3 is a patient heterozygous for the prothrombin G20210A mutation), lane 6 is a positive control for prothrombin G20210A, lane 7 is a positive control for factor V Leiden, and lane 8 is a no DNA negative control. (c) Wild-type reaction for MTHFR. (d) Mutant reaction for MTHFR. In (c and d), lane 1 is a 100bp ladder, lanes 2 and 3 are experimental patient samples, and lane 4 is no DNA control. Note there is an extra band in both the (c and d) gels which represents primer dimers. Kidney International 2006 70, 743-750DOI: (10.1038/sj.ki.5001551) Copyright © 2006 International Society of Nephrology Terms and Conditions