Circulating and cellular adiponectin in polycystic ovary syndrome: relationship to glucose tolerance and insulin action Vanita Aroda, M.D., Theodore.

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Presentation transcript:

Circulating and cellular adiponectin in polycystic ovary syndrome: relationship to glucose tolerance and insulin action Vanita Aroda, M.D., Theodore P. Ciaraldi, Ph.D., Sang-Ah Chang, M.D., Michael H. Dahan, M.D., R. Jeffrey Chang, M.D., Robert R. Henry, M.D. Fertility and Sterility Volume 89, Issue 5, Pages 1200-1208 (May 2008) DOI: 10.1016/j.fertnstert.2007.04.046 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Whole body insulin action (insulin-stimulated glucose disposal rate) (A) and circulating adiponectin levels (B) in normal cycling control subjects (control [Cont], n = 6) and subjects with polycystic ovary syndrome (PCOS) categorized as normal glucose tolerant (NGT, n = 13), and impaired glucose response (IGR, n = 18). All values reported as average ±SEM. ∗P<.02 vs. control. Fertility and Sterility 2008 89, 1200-1208DOI: (10.1016/j.fertnstert.2007.04.046) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Distribution of adiponectin between multimers in the serum of control, normal glucose tolerant– polycystic ovary syndrome (NGT-PCOS) and impaired glucose response (IGR)-PCOS subjects. Equal amounts (2 μL) of serum loaded for each individual. (A) Representative Western blots of 2%–8 % tris-acetate gels run under nonreducing conditions. (B) Quantitation of blots. Results are expressed as percent of the total densitometric signal for each individual, within each lane. Results are average ±SEM, n = 6 for control, 10 for NGT, 16 for IGR. ∗P<.05 vs. control (Cont). HMW = high molecular weight; MMW = medium molecular weight; LMW = low molecular weight. Fertility and Sterility 2008 89, 1200-1208DOI: (10.1016/j.fertnstert.2007.04.046) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Distribution of adiponectin between multimers in adipocytes of control, normal glucose tolerant– polycystic ovary syndrome (PCOS) and impaired glucose response-PCOS subjects. (A) Representative Western blots. Equal amounts of cell protein (10 mg) loaded for each individual. (B) Quantitation of blots. Results are expressed as percent of the total densitometric signal in each lane for each individual. Results are average ±SEM, n = 6 for control, 6 for NGT, and 16 for IGR. ∗P<.05 vs. control (Cont). HMW = high molecular weight; MMW = medium molecular weight; LMW = low molecular weight. Fertility and Sterility 2008 89, 1200-1208DOI: (10.1016/j.fertnstert.2007.04.046) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions