BIRC6 confers resistance against cisplatin and oxaliplatin.

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BIRC6 confers resistance against cisplatin and oxaliplatin. BIRC6 confers resistance against cisplatin and oxaliplatin.A, Western blot analysis of BIRC6 expression in L145 colonospheres transduced with control (luciferase, 57) and BIRC6 knockdown vectors (58, 59). B, Control and BIRC6 knockdown L145 colonospheres were treated with oxaliplatin or cisplatin for 3 days using the indicated concentrations. Cell viability was then assessed by MTS assays for mitochondrial activity. Absorbance values (in triplicate) are expressed as percentage of vehicle-treated control wells. *Statistical significance (unpaired, 2-tailed t test: p < 0.05). WJ Van Houdt et al. Mol Cell Proteomics 2011;10:M111.011353 © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.