Esophageal Diameter Is Decreased in Some Patients With Eosinophilic Esophagitis and Might Increase With Topical Corticosteroid Therapy  Joohee Lee, James Huprich, Christine Kujath, Karthik Ravi, Felicity Enders, Thomas C. Smyrk, David A. Katzka, Nicholas J. Talley, Jeffrey A. Alexander  Clinical Gastroenterology and Hepatology  Volume 10, Issue 5, Pages 481-486 (May 2012) DOI: 10.1016/j.cgh.2011.12.042 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 Technique for determining EDmax. Full-column image of maximally distended esophagus. Maximum and minimum diameter selected between aortic arch level and esophageal ampulla/hiatal hernia (asterisk). In this case of small caliber esophagus, the EDmax and EDmin are 21 and 18 mm, respectively. Clinical Gastroenterology and Hepatology 2012 10, 481-486DOI: (10.1016/j.cgh.2011.12.042) Copyright © 2012 AGA Institute Terms and Conditions

Figure 2 EDs are decreased in EoE. Baseline EDmax was significantly decreased in EoE at 19 vs 24 mm in healthy control subjects (P = .004; **statistical significance). Similarly, baseline EDmin trended toward being lower at 16.3 vs 20.2 mm in control subjects (P = .06). EDmin of patient with EDminE of 10.8 mm (narrowing distal to segment from which EDmin and EDmax were measured) is indicated with a star symbol. Clinical Gastroenterology and Hepatology 2012 10, 481-486DOI: (10.1016/j.cgh.2011.12.042) Copyright © 2012 AGA Institute Terms and Conditions

Figure 3 Significant increase in poststeroid EDmax only seen in subset of those with abnormal baseline EDmax. Median increase in poststeroid EDmax was not statistically significant (P = .15). However, significance was demonstrated in a subset analysis of the 6 individuals with baseline abnormal EDmax (2 mm; P = .01; **statistical significance). Note: 2 patients had the same prepost values of EDmax, which explains why there are 5 visible plots to represent 6 patients. Similarly, with EDmin (data not illustrated), posttreatment increases were not significant in the whole group (P = .1) but did reach significance when considering only the 5 individuals with baseline abnormal EDmin (3 mm; P = .02). Esophagrams were reproducible among controls, as indicated by insignificant variance (P = .44). Clinical Gastroenterology and Hepatology 2012 10, 481-486DOI: (10.1016/j.cgh.2011.12.042) Copyright © 2012 AGA Institute Terms and Conditions