Concentrations of abemaciclib in plasma and cerebrospinal fluid (CSF).

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Dose and range (mg/kg body weight)

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Presentation transcript:

Concentrations of abemaciclib in plasma and cerebrospinal fluid (CSF). Concentrations of abemaciclib in plasma and cerebrospinal fluid (CSF). Geometric mean time course of abemaciclib plasma concentration (A) after single oral dose of abemaciclib ranging from 50 to 275 mg and (B) at steady state on once-daily (Q24H) and twice-daily (Q12H) schedules. Observations below the limit of quantitation of the assay were excluded from the analysis. C, paired plasma and cerebrospinal fluid concentrations of abemaciclib at steady state. Amita Patnaik et al. Cancer Discov 2016;6:740-753 ©2016 by American Association for Cancer Research