A Recyclable Fluorous (S)-Pyrrolidine Sulfonamide Promoted Direct, Highly Enantioselective Aldol Reactions of Ketones and Aldehydes with Aldehydes in Water.

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Presentation transcript:

A Recyclable Fluorous (S)-Pyrrolidine Sulfonamide Promoted Direct, Highly Enantioselective Aldol Reactions of Ketones and Aldehydes with Aldehydes in Water Wei Wang, Department of Chemistry & Chemical Biology, University of New Mexico Environmental concerns associated with chemical processes have encouraged the development more environmentally friendly (greener) organic reactions. In recent years, reactions that take place in the environmentally clean, safe and cheap solvent water have received considerable interest. We have developed the easily separated and reusable fluorous (S)-pyrroldine sulfonamide organocatalyst for promoting highly enantio- and diastereo-selective Aldol addition reactions of ketones and aldehydes with aromatic aldehdyes in water. The organocatalyst is conveniently recovered from the reaction mixtures by fluorous solid-phase extraction and can be subsequently reused (up to 7 cycles) without a significant loss of catalytic activity and stereoselectivity.