Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: A 12- month follow-up analysis Pranabashis Haldar, MD, Christopher E. Brightling,

Slides:

Advertisements

Similar presentations

Thank You This PowerPoint document contains the images that you requested. Copyright Notice All Online Service materials, including, without limitation,

Advertisements

Buffering airway acid decreases exhaled nitric oxide in asthma Benjamin Gaston, MD, Robin Kelly, RN, Peter Urban, RN, Lei Liu, PhD, Edward M. Henderson,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life Carina Venter, BSc, Brett Pereira, MRCP, Jane.

Alveolar nitric oxide and asthma control in mild untreated asthma

Simultaneously increased fraction of exhaled nitric oxide levels and blood eosinophil counts relate to increased asthma morbidity Andrei Malinovschi,

Risk of an asthma exacerbation after bariatric surgery in adults

Reduced exhaled nitric oxide values in children with asthma after inpatient rehabilitation at high altitude Johannes Huss-Marp, MD, Ursula Krämer, PhD,

Pharmacologic rationale for treating allergic and nonallergic rhinitis

Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S

Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life Carina Venter, BSc, Brett Pereira, MRCP, Jane.

Alalia Berry, MD, William W. Busse, MD

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Stephen J. Fowler, MD, Gaël Tavernier, PhD, Robert Niven, MD

Current application of exhaled nitric oxide in clinical practice

Is 9 more than 2 also in allergic airway inflammation?

Desensitization to Chemotherapeutic Agents

Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: A random-sample population study Asger Sverrild, MD, Celeste Porsbjerg,

Airway inflammation in patients with asthma with high-fixed or low-fixed plus as-needed budesonide/formoterol Ian D. Pavord, DM, FRCP, Peter K. Jeffery,

Lung function decline and variable airway inflammatory pattern: Longitudinal analysis of severe asthma Christopher Newby, PhD, Joshua Agbetile, MRCP,

Eosinophil protein in airway macrophages: A novel biomarker of eosinophilic inflammation in patients with asthma Neeta S. Kulkarni, MD, Fay Hollins,

Steven W. Yancey, MSc, Hector G. Ortega, MD, Oliver N

Quantitative computed tomography–derived clusters: Redefining airway remodeling in asthmatic patients Sumit Gupta, PhD, MRCP, Ruth Hartley, MBChB, MRCS,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Allergy testing in predicting outcome of open food challenge to peanut

Nonadherence to Asthma Treatment: Getting Unstuck

Peter M. Wolfgram, MD, David B. Allen, MD

Etiology of asthma exacerbations

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Reply Journal of Allergy and Clinical Immunology

Daily home measurements of exhaled nitric oxide in asthmatic children during natural birch pollen exposure Signe Vahlkvist, MD, Marianne Sinding, Kirsten.

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

What are the best outcome measurements for atopic eczema

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Effect of ingested H1 antihistamines on methacholine challenge

Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: A random-sample population study Asger Sverrild, MD, Celeste Porsbjerg,

What is an “eosinophilic phenotype” of asthma?

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis Salman Siddiqui, MRCP, Amanda Sutcliffe, BSc (Hons), Aarti Shikotra,

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Geographic variability in childhood asthma prevalence in Chicago

Effectiveness of voriconazole in the treatment of Aspergillus fumigatus–associated asthma (EVITA3 study) Joshua Agbetile, MD, Michelle Bourne, RGN, Abbie.

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

Alexandra Kazaks, MA, RD, Janet Y. Uriu-Adams, PhD, Judith S

Prevention of food allergy: Beyond peanut

Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children Daniel J. Jackson, MD, Christine.

The National Institutes of Allergy and Infectious Diseases networks on asthma in inner- city children: An approach to improved care William W. Busse,

Fluctuation phenotyping based on daily fraction of exhaled nitric oxide values in asthmatic children Georgette Stern, MSc, Johan de Jongste, MD, Ralf.

Lars Pedersen, MD, PhD, Thomas K

Measles and immunomodulation

A pilot study of equal doses of 10% IGIV given intravenously or subcutaneously Shilpa H. Desai, BS, MD, Akhil Chouksey, MD, John Poll, RN, Melvin Berger,

The Editors' Choice Journal of Allergy and Clinical Immunology

Päivi M. Salo, PhD, Samuel J. Arbes, DDS, MPH, PhD, Patrick W

Macrolide antibiotics and asthma treatment

Neil W. Johnston, MSc, Sebastian L. Johnston, MD, PhD, Joanne M

Asthma: The past, future, environment, and costs

Daniel Menzies, MBChB, Arun Nair, MBBS, Karen T

Eight-year outcomes of the Childhood Asthma Prevention Study

Environmental factors and eosinophilic esophagitis

Valérie Bougault, PhD, Julie Turmel, MSc, Louis-Philippe Boulet, MD

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Advances in pediatric asthma in 2007

Safety and efficacy of repeated monthly carboplatin desensitization

Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Modeling asthma exacerbations through lung function in children

Presentation transcript:

Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: A 12- month follow-up analysis Pranabashis Haldar, MD, Christopher E. Brightling, PhD, Amisha Singapuri, BSc, Beverley Hargadon, BSc, Sumit Gupta, PhD, William Monteiro, BSc, Peter Bradding, PhD, Ruth H. Green, MD, Andrew J. Wardlaw, PhD, Hector Ortega, PhD, Ian D. Pavord, DM Journal of Allergy and Clinical Immunology Volume 133, Issue 3, Pages 921-923 (March 2014) DOI: 10.1016/j.jaci.2013.11.026 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Comparison of change in inflammatory parameters, severe exacerbation rate, and clinical measures between study groups. Variable measurements presented are the group mean, with error bars representing the standard error of the mean at the time of study entry (prestudy), at the end of the treatment phase (end of study), and at sequential visits during the 12-month observation period. Blood and sputum eosinophil counts and Feno are presented as the geometric mean, with error bars representing log standard error of the mean. Feno, Fraction of exhaled nitric oxide. Journal of Allergy and Clinical Immunology 2014 133, 921-923DOI: (10.1016/j.jaci.2013.11.026) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Journal of Allergy and Clinical Immunology 2014 133, 921-923DOI: (10.1016/j.jaci.2013.11.026) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions