Tylosis esophageal cancer locus on chromosome 17q25

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Tylosis esophageal cancer locus on chromosome 17q25 Tylosis esophageal cancer locus on chromosome 17q25.1 is commonly deleted in sporadic human esophageal cancer Takeshi Iwaya*, Chihaya Maesawa*, Satoshi Ogasawara‡, Gen Tamura* Gastroenterology Volume 114, Issue 6, Pages 1206-1210 (June 1998) DOI: 10.1016/S0016-5085(98)70426-3 Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 1 Representative illustrations of microsatellite analysis in 4 patients (E74, E121, E115, and E59) with ESC. Arrowheads indicate the lost allele. N, normal DNA; T, tumor DNA. Gastroenterology 1998 114, 1206-1210DOI: (10.1016/S0016-5085(98)70426-3) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 2 Results of PCR microsatellite assay on 17q in 43 ESCs exhibiting LOH and/or RER. Physical map of the microsatellite markers is shown at the lower side of the karyogram. Black and white boxes indicate LOH and retained heterozygosity, respectively. Blanks indicate noninformative markers. Group A (E17–126), total deletion; B (E7–119), LOH including both TOC and BRCA1; C (E16–121), tumors with LOH restricted at the TOC locus; D (E76–116 and E91–104), LOH at two or three distinct regions; E (E99 and 111), others. Gastroenterology 1998 114, 1206-1210DOI: (10.1016/S0016-5085(98)70426-3) Copyright © 1998 American Gastroenterological Association Terms and Conditions