Addressing resistance evolution in Pseudomonas aeruginosa using pharmacodynamic modelling: application to meropenem dosage and combination therapy L.

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Presentation transcript:

Addressing resistance evolution in Pseudomonas aeruginosa using pharmacodynamic modelling: application to meropenem dosage and combination therapy L. Santos Filho, K.J. Eagye, J.L. Kuti, D.P. Nicolau Clinical Microbiology and Infection Volume 13, Issue 6, Pages 579-585 (June 2007) DOI: 10.1111/j.1469-0691.2007.01693.x Copyright © 2007 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Distribution of MICs for 208 isolates of Pseudomonas aeruginosa, displayed as a percentage of total isolates. Clinical Microbiology and Infection 2007 13, 579-585DOI: (10.1111/j.1469-0691.2007.01693.x) Copyright © 2007 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Probability of bactericidal target attainment using various regimens of meropenem, with a target of 40% fT>MIC (INF, infusion; q8h, every 8 h; PTA, probability of target attainment). Clinical Microbiology and Infection 2007 13, 579-585DOI: (10.1111/j.1469-0691.2007.01693.x) Copyright © 2007 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3 Probability of bacteriostatic target attainment using various regimens of meropenem against Pseudomonas aeruginosa with a target of 20% fT>MIC (INF, infusion; q8h, every 8 h; PTA, probability of target attainment). Clinical Microbiology and Infection 2007 13, 579-585DOI: (10.1111/j.1469-0691.2007.01693.x) Copyright © 2007 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 4 Probability of target attainment (PTA) of various meropenem regimens when the target is a CMIN/MIC of ≥6.2 (INF, infusion; q8h, every 8 h). Clinical Microbiology and Infection 2007 13, 579-585DOI: (10.1111/j.1469-0691.2007.01693.x) Copyright © 2007 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 5 Probability of target attainment (PTA) of various regimens of meropenem when the target is a CMIN/MIC of ≥1.7 (INF, infusion; q8h, every 8 h). Clinical Microbiology and Infection 2007 13, 579-585DOI: (10.1111/j.1469-0691.2007.01693.x) Copyright © 2007 European Society of Clinical Infectious Diseases Terms and Conditions