High Expression Levels of Keratinocyte Antimicrobial Proteins in Psoriasis Compared with Atopic Dermatitis Gys J. de Jongh, Patrick L.J.M. Zeeuwen, Martina.

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High Expression Levels of Keratinocyte Antimicrobial Proteins in Psoriasis Compared with Atopic Dermatitis Gys J. de Jongh, Patrick L.J.M. Zeeuwen, Martina Kucharekova, Rolph Pfundt, Pieter G. van der Valk, Willeke Blokx, Aynur Dogan, Pieter S. Hiemstra, Peter C. van de Kerkhof, Joost Schalkwijk Journal of Investigative Dermatology Volume 125, Issue 6, Pages 1163-1173 (December 2005) DOI: 10.1111/j.0022-202X.2005.23935.x Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Host defense proteins in human skin. Immunohistochemical staining of normal skin, atopic dermatitis skin, and psoriatic skin for elafin, human β-defensin (hBD)-2, hBD-3, calgranulin A, and secretory leukocyte proteinase inhibitor (SLPI). Note the strong difference in staining intensity for elafin, hBD-2, and SLPI between psoriasis and atopic dermatitis. Staining for hBD-3 was variable, and not significantly different between the two diseases. The brown staining of the basal layer in (d) and (j) is caused by melanin and does not represent positive staining for hBD-2 or calgranulin A. Scale bar: 50 μm. Journal of Investigative Dermatology 2005 125, 1163-1173DOI: (10.1111/j.0022-202X.2005.23935.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Differentiation and proliferation in psoriasis and atopic dermatitis. Immunohistochemical staining of atopic dermatitis skin and psoriatic skin for involucrin, CK16, and Ki-67. Note the similar localization and staining intensities of these markers in the two diseases. Scale bar: 100 μm. Journal of Investigative Dermatology 2005 125, 1163-1173DOI: (10.1111/j.0022-202X.2005.23935.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions