Ketamine* Journal of Pain and Symptom Management

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Ketamine* Journal of Pain and Symptom Management Rachel Quibell, MRCGP, Eric E. Prommer, MD, Mary Mihalyo, BS, PharmD, RPh, Robert Twycross, DM, FRCP, Andrew Wilcock, DM, FRCP  Journal of Pain and Symptom Management  Volume 41, Issue 3, Pages 640-649 (March 2011) DOI: 10.1016/j.jpainsymman.2011.01.001 Copyright © 2011 Terms and Conditions

Figure Diagram of NMDA (excitatory) receptor-channel complex. The channel is blocked by Mg2+ when the membrane potential is at its resting level (voltage-dependent block) and by drugs that act at the phencyclidine (PCP) binding site in the glutamate-activated channel, e.g., dextromethorphan, ketamine, methadone (use-dependent block).4 Figure reproduced by permission of palliativedrugs.com Ltd. Journal of Pain and Symptom Management 2011 41, 640-649DOI: (10.1016/j.jpainsymman.2011.01.001) Copyright © 2011 Terms and Conditions

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