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Nat. Rev. Cardiol. doi:10.1038/nrcardio.2014.85 Figure 1 A schematic representation of the cardiac action potential with the major contributing cardiac ion channel currents Figure 1 reprinted from Liu, M., Brahmanandam, V. M. & Dudley, S. C. Jr in Biophysics of the Failing Heart: Physics and Biology of Heart Muscle, 1st edn Ch. 4 Biophysics of Membrane Currents in Heart Failure (eds Solaro, R. J. & Tardif, J. C.) 63–90 (Springer, 2013), with kind permission from Springer Science and Business Media Liu, M. et al. (2014) Cardiac sodium channel mutations: why so many phenotypes? Nat. Rev. Cardiol. doi:10.1038/nrcardio.2014.85