Impaired response of the denervated kidney to endothelin receptor blockade in normotensive and spontaneously hypertensive rats Radoslav Girchev, Angela.

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Impaired response of the denervated kidney to endothelin receptor blockade in normotensive and spontaneously hypertensive rats Radoslav Girchev, Angela Bäcker, Petia Markova, Herbert J. Kramer Kidney International Volume 65, Issue 3, Pages 982-989 (March 2004) DOI: 10.1111/j.1523-1755.2004.00483.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Urine flow rate (A) and sodium (B) and potassium (C) excretion in intact Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR) and in denervated WKY rats (WKYD) and denervated SHR (SHRD). Symbols are: (□) control; (▪) intravenous infusion of 16.4nmol/kg/min BQ-123; (□) intravenous infusion of 25nmol/kg/min BQ-788. *P < 0.05; **P < 0.01, BQ-123 vs. control; ++P < 0.001, BQ-788 vs. control; #P < 0.05, WKYD vs. WKY. Kidney International 2004 65, 982-989DOI: (10.1111/j.1523-1755.2004.00483.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Tissue endothelin-1 (ET-1) content in renal cortex (A) and papilla (B) in intact Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR), and in denervated WKY rats (WKYD) and denervated SHR (SHRD) (eachN = 6).#P < 0.001 WKYD vs. WKY rats; **P < 0.01 SHR vs. WKY rats; ++P < 0.01 SHRD vs. WKYD. Kidney International 2004 65, 982-989DOI: (10.1111/j.1523-1755.2004.00483.x) Copyright © 2004 International Society of Nephrology Terms and Conditions