Microparticles in nasal lavage fluids in chronic rhinosinusitis: Potential biomarkers for diagnosis of aspirin-exacerbated respiratory disease Toru Takahashi,

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Microparticles in nasal lavage fluids in chronic rhinosinusitis: Potential biomarkers for diagnosis of aspirin-exacerbated respiratory disease Toru Takahashi, MD, PhD, Atsushi Kato, PhD, Sergejs Berdnikovs, PhD, Whitney W. Stevens, MD, PhD, Lydia A. Suh, BS, James E. Norton, MS, Roderick G. Carter, BS, Kathleen E. Harris, BS, Anju T. Peters, MD, Kathryn E. Hulse, PhD, Leslie C. Grammer, MD, Kevin C. Welch, MD, Stephanie Shintani-Smith, MD, Bruce K. Tan, MD, David B. Conley, MD, Robert C. Kern, MD, Bruce S. Bochner, MD, Robert P. Schleimer, PhD Journal of Allergy and Clinical Immunology Volume 140, Issue 3, Pages 720-729 (September 2017) DOI: 10.1016/j.jaci.2017.01.022 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Comparison of MPs among subjects with CRSsNP, subjects with CRSwNP, subjects with AERD, and control subjects. A, ActEndoMPs. B, EndoMPs. C, EpCAM+EpiMPs. D, E-cad+EpiMPs. E, PltMPs. F, EoMPs. G, ActEoMPs. H, ApoEoMPs. I, MCMPs. J, ActMCMPs. K, AV+MCMPs. L, BasoMPs. M, ApoBasoMPs. *P < .05. **P < .01. ***P < .001. Journal of Allergy and Clinical Immunology 2017 140, 720-729DOI: (10.1016/j.jaci.2017.01.022) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Comparison of mean fluorescence intensity (MFI) of CD203c on BasoMPs among subjects with CRSsNP, subjects with CRSwNP, subjects with AERD, and control subjects. **P < .01 and ***P < .001. Journal of Allergy and Clinical Immunology 2017 140, 720-729DOI: (10.1016/j.jaci.2017.01.022) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Receiver operating characteristic curve of PltMP, EpCAM+EpiMP, E-cad+EpiMP, and AV+MCMP levels for distinguishing subjects with AERD from subjects with CRSwNP. A, PltMPs. B, EpCAM+EpiMPs. C, E-cad+EpiMPs. D, AV+MCMPs. Journal of Allergy and Clinical Immunology 2017 140, 720-729DOI: (10.1016/j.jaci.2017.01.022) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Released MP types and levels in subjects with CRSwNP and subjects with AERD. Text on right indicates difference in CRSwNP compared to control. Red asterisk indicates those in which values are higher in AERD than in CRSwNP. Journal of Allergy and Clinical Immunology 2017 140, 720-729DOI: (10.1016/j.jaci.2017.01.022) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions