Michael R. Goldberg, MD, PhD, Liat Nachshon, MD, Michael Y

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Efficacy of baked milk oral immunotherapy in baked milk–reactive allergic patients Michael R. Goldberg, MD, PhD, Liat Nachshon, MD, Michael Y. Appel, PhD, Arnon Elizur, MD, Michael B. Levy, MD, Eli Eisenberg, PhD, Hugh A. Sampson, MD, Yitzhak Katz, MD Journal of Allergy and Clinical Immunology Volume 136, Issue 6, Pages 1601-1606 (December 2015) DOI: 10.1016/j.jaci.2015.05.040 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Clinical progression and biological parameters in patients undergoing BM OIT. A, BM dose (in milligrams) progression for patients greater than 3 months in treatment. B, Immunoblot analysis (top panels) against CMP using patients' sera at 0 and 12 months and corresponding membrane Ponceau S staining (bottom panels) are presented. Patients 8 to 13 are labeled with their final disposition in the BM OIT program. Solid box, Completed BM OIT; hatched box, failed to complete the program. κ, 5 μg of semipurified bovine-derived milk κ-casein; kDa, molecular weight markers in kilodaltons; M, CMP (28 μg). Journal of Allergy and Clinical Immunology 2015 136, 1601-1606DOI: (10.1016/j.jaci.2015.05.040) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Desensitization to UM. The median maximum tolerated dose from OFC of UM at T0, T6, and T12 grouped according to disposition in BM OIT after 12 months of treatment is shown. Blue column, n = 6 for all patients reaching the 12-month mark; green column, n = 3 for those successfully reaching the maintenance goal; red column, n = 3 for failures. *P = .003, Mann-Whitney U test. z = −2.8, comparing the T12 and T0 tolerated dose. Milk(U), Unheated milk. Journal of Allergy and Clinical Immunology 2015 136, 1601-1606DOI: (10.1016/j.jaci.2015.05.040) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Relationship between disposition in BM OIT and initial differential basophil reactivity to HM and UM. T0 basophil reactivity induced by 100 ng/mL HM subtracted by that induced by 100 ng/mL UM is presented as the mean ± SE (bars) of CD203c and CD63 expression in those successfully completing the program (Success, n = 3) and in those who stopped because of IgE-mediated reactions (Failure, n = 6). Milk(U), Unheated milk. Journal of Allergy and Clinical Immunology 2015 136, 1601-1606DOI: (10.1016/j.jaci.2015.05.040) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions