Block of postjunctional muscle-type acetylcholine receptors in vivo causes train-of-four fade in mice M. Nagashima, T. Sasakawa, S.J. Schaller, J.A.J.

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Block of postjunctional muscle-type acetylcholine receptors in vivo causes train-of-four fade in mice M. Nagashima, T. Sasakawa, S.J. Schaller, J.A.J. Martyn British Journal of Anaesthesia Volume 115, Issue 1, Pages 122-127 (July 2015) DOI: 10.1093/bja/aev037 Copyright © 2015 The Author(s) Terms and Conditions

Fig 1 Intravenous administration of DHβE alone causes no significant neuromuscular effect on twitch tension or fade. Following intravenous administration of 1.0 µg g−1 DHβE, twitch tension and train-of-four (TOF) ratio were measured for 90 min. No significant change in twitch tension (N: Newton) and train-of-four ratio (n=6). Box and whisker plots show median, 25th and 75th percentiles and full ranges. British Journal of Anaesthesia 2015 115, 122-127DOI: (10.1093/bja/aev037) Copyright © 2015 The Author(s) Terms and Conditions

Fig 2 Postsynaptic block of muscle nAChRs by α-BTX causes train-of-four fade which was potentiated by DHβE. Following intravenous administration of α-BTX 0.175 µg g−1 with or without DHβE, the train-of-four (TOF) ratio was measured. The postjunctional block of nAChRs by α-BTX alone produced significant fade (n=6). This fade was potentiated by block of prejunctional α3β2 nAChR by DHβE [0.5 µg g−1 (n=6) or 1.0 µg g−1 (n=6)]. Box and whisker plots show median, 25th and 75th percentiles and full ranges. aP<0.01 vs pre-drug administration value of TOF ratio. bP<0.01 vs TOF fade by α-BTX at same degree of T1 depression. British Journal of Anaesthesia 2015 115, 122-127DOI: (10.1093/bja/aev037) Copyright © 2015 The Author(s) Terms and Conditions

Fig 3 Postsynaptic block of muscle nAChRs by α-conotoxin GI leads to train-of-four fade which was accentuated by DHβE. After intravenous α-conotoxin GI 30 ng g−1 with or without DHβE (1.0 µg g−1), the TOF ratio was measured. Postjunctional nAChR antagonist, α-conotoxin GI, produced significant fade (n=5), which was potentiated by prejunctional block of nAChRs by DHβE (n=5). Box and whisker plots show median, 25th and 75th percentiles and full ranges. aP<0.01 vs pre-drug administration value of TOF ratio. bP<0.01 vs TOF fade by α-BTX at same degree of T1 depression. British Journal of Anaesthesia 2015 115, 122-127DOI: (10.1093/bja/aev037) Copyright © 2015 The Author(s) Terms and Conditions