Lymphomatoid Granulomatosis: Past, Present,…Future?

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Presentation transcript:

Lymphomatoid Granulomatosis: Past, Present,…Future? Jeffrey L. Myers, M.D. Mayo Clinic Proceedings Volume 65, Issue 2, Pages 274-278 (February 1990) DOI: 10.1016/S0025-6196(12)65021-6 Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 A, Low-magnification photomicrograph of lymphomatoid granulomatosis, showing dense lymphoid infiltrate associated with tumor necrosis on the right. (Hematoxylin-eosin; original magnification x100.) B, Higher magnification photomicrograph, showing polymorphic composition of lymphoid infiltrate that includes mainly small lymphocytes and plasma cells admixed with a few large atypical mononuclear cells. (Hematoxylin-eosin; original magnification x200.) Mayo Clinic Proceedings 1990 65, 274-278DOI: (10.1016/S0025-6196(12)65021-6) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 2 Photograph of excised pulmonary nodule in a patient with lymphomatoid granulomatosis. In this well-circumscribed nodule, central necrosis is surrounded by a rim of firm white tissue. Gross features are similar to those seen in necrotizing infectious granulomas. Mayo Clinic Proceedings 1990 65, 274-278DOI: (10.1016/S0025-6196(12)65021-6) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 3 Photomicrograph showing extensive vascular infiltration in lymphomatoid granulomatosis. Vessel wall contains a transmural infiltrate of lymphoid cells, which has reduced the lumen to a slitlike space. (Hematoxylin-eosin; original magnification x100.) Mayo Clinic Proceedings 1990 65, 274-278DOI: (10.1016/S0025-6196(12)65021-6) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions